Results 11 to 20 of about 1,582,116 (88)

Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity

Cancers, 2019
Chromosome instability (CIN) is defined as an increased rate of chromosome gains and losses that manifests as cell-to-cell karyotypic heterogeneity and drives cancer initiation and evolution.
Chloe C. Lepage, Claire R Morden, Michaela C L Palmer, M. Nachtigal, K. McManus   +4 more
semanticscholar   +1 more source

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.

Cancer Cell, 2018
Breast cancer is the second leading cause of cancer-related death among women. Here we report a role for the protein kinase p38α in coordinating the DNA damage response and limiting chromosome instability during breast tumor progression, and identify the
Begoña Cánovas, Ana Igea, A. Sartori, R. Gomis, T. Paull, Michitaka Isoda, H. Pérez-Montoyo, V. Serra, E. González-Suárez, T. Stracker, A. Nebreda   +10 more
semanticscholar   +1 more source

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.

Cancer Discovery, 2018
ADP-ribosylation is an important posttranslational protein modification that regulates diverse biological processes, controlled by dedicated transferases and hydrolases.
A. Sakthianandeswaren, Marie J Parsons, D. Mouradov, R. MacKinnon, B. Catimel, Sheng Liu, M. Palmieri, C. Love, R. Jorissen, Shan Li, L. Whitehead, Tracy L. Putoczki, Adele Preaudet, C. Tsui, C. Nowell, R. Ward, N. Hawkins, J. Desai, P. Gibbs, M. Ernst, I. Street, M. Buchert, O. Sieber   +22 more
semanticscholar   +1 more source

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

Oncogene, 2018
MASTL kinase is essential for correct progression through mitosis, with loss of MASTL causing chromosome segregation errors, mitotic collapse and failure of cytokinesis. However, in cancer MASTL is most commonly amplified and overexpressed.
Samuel Rogers, R. McCloy, Benjamin L. Parker, D. Gallego-Ortega, Andrew M. K. Law, V. Chin, James R W Conway, D. Fey, Ewan K. A. Millar, S. O'toole, N. Deng, A. Swarbrick, Paul D. Chastain, Anthony J. Cesare, P. Timpson, C. E. Caldon, D. Croucher, David E. James, D. N. Watkins, A. Burgess   +19 more
semanticscholar   +1 more source

Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer

Cancers, 2017
Cancer is a devastating disease that claims over 8 million lives each year. Understanding the molecular etiology of the disease is critical to identify and develop new therapeutic strategies and targets.
L. L. Thompson, Lucile M. Jeusset, Chloe C. Lepage, K. McManus   +3 more
semanticscholar   +1 more source

Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

Journal of Cancer Metastasis and Treatment, 2018
Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis.
Shirley Jusino, Fabiola M. Fernández-Padín, H. Saavedra   +2 more
semanticscholar   +1 more source

Transient ALT activation protects human primary cells from chromosome instability induced by low chronic oxidative stress

Scientific Reports, 2017
Cells are often subjected to the effect of reactive oxygen species (ROS) as a result of both intracellular metabolism and exposure to exogenous factors.
E. Coluzzi, R. Buonsante, S. Leone, A. Asmar, K. Miller, D. Cimini, A. Sgura   +6 more
semanticscholar   +1 more source

Whole Chromosome Instability induces senescence and promotes SASP

Scientific Reports, 2016
Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions.
G. Andriani, Vinnycius Pereira Almeida, Francesca Faggioli, M. Mauro, W. Tsai, L. Santambrogio, A. Maslov, M. Gadina, J. Campisi, J. Vijg, C. Montagna   +10 more
semanticscholar   +1 more source

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

Cell Reports, 2016
Summary Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages.
Konstantina Rowald, M. Mantovan, J. Passos, Christopher Buccitelli, Balca R. Mardin, J. Korbel, M. Jechlinger, R. Sotillo   +7 more
semanticscholar   +1 more source

Extraordinary Genome Instability and Widespread Chromosome Rearrangements During Vegetative Growth

Genetics, 2018
The ability to rapidly adapt to changing environments is crucial for the success of pathogens infecting plants and animals. In some eukaryotic pathogens, rapid evolution can be mediated by genome rearrangements, which...
Mareike Möller, M. Habig, M. Freitag, E. Stukenbrock   +3 more
semanticscholar   +1 more source