Results 21 to 30 of about 1,582,116 (88)

Topoisomerase IIα in Chromosome Instability and Personalized Cancer Therapy

Oncogene, 2014
Genome instability is a hallmark of cancer cells. Chromosome instability (CIN), which is often mutually exclusive from hypermutation genotypes, represents a distinct subtype of genome instability.
Tao Chen, Yan Sun, P. Ji, S. Kopetz, Wei Zhang   +4 more
semanticscholar   +1 more source

Chromosome Instability in mouse Embryonic Stem Cells

Scientific Reports, 2014
Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell lines when maintained in vitro.
N. Gaztelumendi, C. Nogués
semanticscholar   +1 more source

Plant speciation through chromosome instability and ploidy change: Cellular mechanisms, molecular factors and evolutionary relevance

, 2014
Plant speciation and diversification strongly rely on structural changes in the nuclear genome, both at the whole ploidy and individual chromosome level.
N. Storme, A. Mason
semanticscholar   +1 more source

Centrosome Dysfunction Contributes to Chromosome Instability, Chromoanagenesis, and Genome Reprograming in Cancer

Frontiers in Oncology, 2013
The unique ability of centrosomes to nucleate and organize microtubules makes them unrivaled conductors of important interphase processes, such as intracellular payload traffic, cell polarity, cell locomotion, and organization of the immunologic synapse.
G. Pihan
semanticscholar   +1 more source

Chromosome instability predicts the progression of premalignant oral lesions.

Oral Oncology, 2013
OBJECTIVES One of the main problems in reducing the incidence of oral squamous cell carcinoma (OSCC) is the inability to appropriately deal with leukoplakia. Accurately identifying lesions which will progress to malignancy is currently not possible.
T. Siebers, Verona E. Bergshoeff, I. Otte-Höller, B. Kremer, E. Speel, Jeroen A. W. M. van der Laak, M. Merkx, P. Slootweg   +7 more
semanticscholar   +1 more source

A Novel Measure of Chromosome Instability Can Account for Prognostic Difference in Multiple Myeloma

PLoS ONE, 2013
Multiple myeloma (MM) is characterized by complex genetic abnormalities whose complexity signifies varying degree of chromosomal instability (CIN).
Tae-Hoon Chung, G. Mulligan, R. Fonseca, W. Chng   +3 more
semanticscholar   +1 more source

Sequencing of Candidate Chromosome Instability Genes in Endometrial Cancers Reveals Somatic Mutations in ESCO1, CHTF18, and MRE11A

PLoS ONE, 2013
Most endometrial cancers can be classified histologically as endometrioid, serous, or clear cell. Non-endometrioid endometrial cancers (NEECs; serous and clear cell) are the most clinically aggressive of the three major histotypes and are characterized ...
J. Price, Lana M. Pollock, Meghan L. Rudd, Sarah K. Fogoros, Hassan Mohamed, Christin L. Hanigan, Matthieu Le Gallo, Nih Intramural Sequencing Center (NISC) Comparative Se Program, Suiyuan Zhang, P. Cruz, Praveen F. Cherukuri, Nancy F. Hansen, K. McManus, A. Godwin, D. Sgroi, J. Mullikin, M. Merino, P. Hieter, D. Bell   +18 more
semanticscholar   +1 more source

The two sides of chromosomal instability: drivers and brakes in cancer

Signal Transduction and Targeted Therapy
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or structural changes ...
R. Hosea, Sharon Hillary, S. Naqvi, Shourong Wu, Vivi Kasim   +4 more
semanticscholar   +1 more source

Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells. [PDF]

Int J Mol Sci, 2023
Toyoda JH, Martino J, Speer RM, Meaza I, Lu H, Williams AR, Bolt AM, Kouokam JC, Aboueissa AE, Wise JP.   +9 more
europepmc   +1 more source

Chromosome instability-associated prognostic signature and cluster investigation for cutaneous melanoma cases. [PDF]

IET Syst Biol, 2023
Liu N, Liu G, Ma Q, Li X.
europepmc   +1 more source