Results 71 to 80 of about 237,732 (314)

Metaphase and Interphase Cytogenetics with Alu-PCR-amplified Yeast Artificial Chromosome Clones Containing the BCR Gene and the Protooncogenes c-raf-1, c-fms, and c-erbB-21 [PDF]

, 1992
A human yeast artificial chromosome (YAC) library was screened by polymerase chain reaction with oligonucleotide primers defined for DNA sequences of the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erB-2.
Olson, Maynard V., Riethman, Harold C., Green, Eric D., Becher, Reinhard, Taniwaki, Masafumi, Michael R. Speicher, Speicher, Michael R., Cremer, Thomas, Christoph Lengauer, Eric D. Green, Konecki, David, Maynard V. Olson, David Konecki, Reinhard Becher, Harold C. Riethman, Lengauer, Christoph, Masafumi Taniwaki, Thomas Cremer   +17 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Physical mapping of the B-hordein loci on barley chromosome 5 by in situ hybridization

, 1989
Physical mapping of the B-hordein genes in barley (Hordeum vulgare cv. Betzes) was achieved by in situ hybridization of a biotin-labelled B-hordein cRNA probe to chromosome spreads.
Archer, S., Simon Archer, Clark, M., Melody Clark, Angela Karp, Karp, A.   +5 more
core   +1 more source

GENETICS AND GENOMICS OF PLANT GENETIC RESOURCES [PDF]

Journal of Stress Physiology & Biochemistry, 2012
Plant genetic resources play a major role for global food security. The most significant and widespread mean of conserving plant genetic resources is ex situ conservation.
Börner A., E.K. Khlestkina, T.A. Pshenichnikova, S.V. Osipova, B. Kobiljski, S. Landjeva, M.R. Simon, M. Nagel, M.A. Rehman Arif, K. Neumann, U. Lohwasser, M.S. Röder   +11 more
doaj  

Common Wheat Chromosome 5B Composition Analysis Using Low-Coverage 454 Sequencing

The Plant Genome, 2014
The sequencing of individual chromosomes of common wheat is in progress. The molecular size of wheat chromosome 5B is nearly 870 Mb (5BL = 580 Mb and 5BS = 290 Mb).
E. M. Sergeeva, D. A. Afonnikov, M. K. Koltunova, V. D. Gusev, L. A. Miroshnichenko, J. Vrána, M. Kubaláková, C. Poncet, P. Sourdille, C. Feuillet, J. Doležel, E. A. Salina   +11 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A specific insertion of a solo-LTR characterizes the Y chromosome of Bryonia dioica (Cucurbitaceae) [PDF]

, 2010
Background: Relatively few species of flowering plants are dioecious and even fewer are known to have sex chromosomes. Current theory posits that homomorphic sex chromosomes, such as found in Bryonia dioica (Cucurbitaceae), offer insight into the early ...
Silber, Martina V., Renner Susanne S, Ryan K Oyama, Oyama Ryan K, Susanne S Renner, Renner, Susanne S., Oyama, Ryan K., Silber Martina V, Martina V Silber   +8 more
core   +1 more source

Quantitative Genetic Mapping and Genome Assembly in the Lesser Wax Moth Achroia grisella

G3: Genes, Genomes, Genetics, 2019
Specific characteristics of the male Achroia grisella acoustic mating signal determine a male’s attractiveness toward females. These features are genetically variable in populations, and mapping experiments have been used to identify loci contributing to
Boryana S. Koseva, Jennifer L. Hackett, Yihong Zhou, Bethany R. Harris, John K. Kelly, Michael D. Greenfield, Jennifer M. Gleason, Stuart J. Macdonald   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Fluorescence in situ hybridization of YAC clones after Alu-PCR amplification [PDF]

, 1992
Alu-PCR protocols were optimized for the generation of human DNA probes from yeast strains containing yeast artificial chromosomes (YACs) with human inserts between 100 and 800 kb in size.
Cremer, Thomas, Green, Eric D., Lengauer, Christoph   +2 more
core   +1 more source