Results 111 to 120 of about 22,467,747 (285)

Development and validation of a bovine macrophage specific cDNA microarray [PDF]

, 2006
Background The response of macrophages to danger signals is an important early stage in the immune response. Our understanding of this complex event has been furthered by microarray analysis, which allows the simultaneous investigation of the expression ...
Waddington David, Jensen Kirsty, Talbot, Richard, Edith Paxton, Talbot Richard, Elizabeth J Glass, Paxton Edith, Paxton, Edith, David Waddington, Kirsty Jensen, Jensen, Kirsty, Glass, Elizabeth, Waddington, David, Glass Elizabeth J, Richard Talbot   +14 more
core   +1 more source

Prenatal Evaluation of RNU4‐2 Variants in Fetuses With Central Nervous System Anomalies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Fetal central nervous system (CNS) anomalies are among the most common congenital malformations, yet the overall prenatal diagnostic yield of current genetic testing remains below 40%. Variants in RNU4‐2, a non‐coding gene encoding the U4 small nuclear RNA (snRNA), have recently been linked to a novel highly recurrent dominant ...
Yiyao Chen, Li Gao, Xu Han, Yunyun Cao, Lanlan Zhang, Yi Wu, Xinrong Zhao, Wenjing Hu, Ruiyu Ma, Renyi Hua, Niu Li, Yanlin Wang, Jian Wang, Shuyuan Li   +13 more
wiley   +1 more source

The dChip survival analysis module for microarray data

BMC Bioinformatics, 2011
Background Genome-wide expression signatures are emerging as potential marker for overall survival and disease recurrence risk as evidenced by recent commercialization of gene expression based biomarkers in breast cancer.
Minvielle Stéphane, Adamia Sophia, Yan Aimin, Shah Parantu K, Amin Samir B, Avet-Loiseau Hervé, Munshi Nikhil C, Li Cheng   +7 more
doaj   +1 more source

Regional regulation of transcription in the chicken genome [PDF]

, 2010
Background Over the past years, the relationship between gene transcription and chromosomal location has been studied in a number of different vertebrate genomes. Regional differences in gene expression have been found in several different species.
Bastiaansen John WM, Nie, H., Nie Haisheng, Crooijmans, R.P.M.A., Groenen, M.A.M., Groenen Martien AM, Bastiaansen, J.W.M., Crooijmans Richard PMA, Megens, H.J.W.C., Megens Hendrik-Jan   +9 more
core   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

A temporal precedence based clustering method for gene expression microarray data [PDF]

, 2010
Background: Time-course microarray experiments can produce useful data which can help in understanding the underlying dynamics of the system. Clustering is an important stage in microarray data analysis where the data is grouped together according to ...
Li Chang-Tsun, Buchanan-Wollaston, Vicky, Chang-Tsun Li, Vicky Buchanan-Wollaston, Krishna, Ritesh V., Ritesh Krishna, Buchanan-Wollaston Vicky, Krishna Ritesh, Li, Chang-Tsun   +8 more
core   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Clinical and Genetic Factors Associated With Regression in Children With Autism Spectrum Disorders

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with complex genetic and environmental underpinnings. A clinically significant subset of children with ASD experience developmental regression (regASD), characterized by the acute loss of previously acquired skills. The mechanisms, predictors, and molecular basis of
Anna Maruani, Emma Delclaud, Paul Bruzeau, Richard Delorme, Anne‐Claude Tabet, Valérie Vantalon, Jonathan Levy, Pierre Ellul   +7 more
wiley   +1 more source

Predicting cisplatin response in cholangiocarcinoma patients using chromosome pattern and related gene expression

Scientific Reports
Cholangiocarcinoma (CCA) is a prevalent bile duct cancer with limited treatment options. Cisplatin-based chemotherapy is a common approach, but response rates vary.
Sutheemon Techa-ay, Sasithorn Watcharadetwittaya, Raksawan Deenonpoe, Kitti Intuyod, Waleeporn Kaewlert, Anchalee Techasen, Watcharin Loilome, Poramate Klanrit, Manida Suksawat, Kwanjira Chaleekan, Sirinya Sitthirak, Malinee Thanee   +11 more
doaj   +1 more source

Dizygotic twin pseudochimaerism initially diagnosed as mosaic Klinefelter syndrome on microarray: case report

BMJ Connections Clinical Genetics and Genomics
Background Chimaerism is a rare genetic condition where an individual possesses two or more distinct cell lines originating from different zygotes. This case report highlights the diagnostic challenge presented by pseudochimaerism in a patient initially ...
Declan O’Rourke, Aisling Lyons, Sumaiya Al-Rashdi, Elizabeth Whitmore, AnnMarie Hegarty   +4 more
doaj   +1 more source