Results 51 to 60 of about 22,467,747 (285)

Chromosomal microarray analysis vs. karyotyping for fetal ventriculomegaly: a meta-analysis

Chinese Medical Journal, 2021
Abstract Background: Chromosomal abnormalities are important causes of ventriculomegaly (VM). In mild and isolated cases of fetal VM, obstetricians rarely give clear indications for pregnancy termination. We aimed to calculate the incidence of chromosomal abnormalities and incremental yield of chromosomal microarray ...
Yan Sun, Weiyuan Zhang, Zhiwen Wang, Likui Guo, Shaowen Shi, Jing Ni   +5 more
openaire   +3 more sources

Multi-membership gene regulation in pathway based microarray analysis [PDF]

, 2011
This article is available through the Brunel Open Access Publishing Fund. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use,
Payne, AM, Pavlidis Stelios P, Swift Stephen M, Stephen M Swift, Pavlidis, SP, Payne Annette M, Swift, SM, Annette M Payne, Stelios P Pavlidis   +8 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Genetic Normalization of Differentiating Aneuploid Human Embryos [PDF]

, 2011
Early embryogenesis involves a series of dynamic processes, many of which are currently not well described or understood. Aneuploidy and aneuploid mosaicism, a mixture of aneuploid and euploid cells within one embryo, in early embryonic development are ...
Paul Brezina, Raymond Anchan, Kevin Richter, Ric Ross, Andrew Benner, William Kearns, Andrew Barker, Khanh-Ha Nguyen, Garry Cutting   +8 more
core  

Prenatal diagnosis of paternal uniparental disomy for chromosome 14 using a single-nucleotide-polymorphism-based microarray analysis: A case report

Journal of the Formosan Medical Association, 2019
Paternal uniparental disomy 14 (UDP(14)pat) is a rare imprinting disorder with a set of unique neonatal clinical features documented, including craniofacial abnormalities, thoracic and abdominal wall defects, and polyhydraminos. To date, no studies focus
Chih-Ling Chen, Chien-Nan Lee, Ming-Wei Lin, Wen-Wei Hsu, Yi-Yun Tai, Shin-Yu Lin   +5 more
doaj   +1 more source

The use of chromosomal microarray analysis for diagnostics of chromosomal pathology in fetal central nervous system malformations

Акушерство, гинекология и репродукция, 2020
Introduction. The prevalence of congenital malformations (CMFs) in fetal central nervous system (CNS) ranges from 1.5 to 3 % and covers around 29 % among all malformations, whereas percentage in the structure of perinatal and infant mortality reaches 25 ...
J. K. Kievskaya, I. V. Kanivets, E. V. Kudryavtseva, D. V. Pyankov, S. A. Korostelev   +4 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Relationship between gene co-expression and probe localization on microarray slides

BMC Genomics, 2003
Background Microarray technology allows simultaneous measurement of thousands of genes in a single experiment. This is a potentially useful tool for evaluating co-expression of genes and extraction of useful functional and chromosomal structural ...
Qian Jiang, Yu Haiyuan, Kluger Yuval, Gerstein Mark   +3 more
doaj   +1 more source

Application of Chromosome Microarray in Diagnosis of Amniotic Fluid in Older Pregnant Women

Clinical and Experimental Obstetrics & Gynecology, 2023
Background: To improve the detection rate of chromosome abnormalities in fetuses and to reduce the birth defects rate in elderly pregnant women using chromosome karyotype analysis combined with the chromosome microarray analysis (CMA) technique. Methods:
Guangting Lu, Weiwu Liu, Chao Ou
doaj   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source