Results 201 to 210 of about 405,684 (326)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Aegilops tauschii Accessions with Geographically Diverse Origin Show Differences in Chromosome Organization and Polymorphism of Molecular Markers Linked to Leaf Rust and Powdery Mildew Resistance Genes [PDF]

, 2017
Maciej Majka, Michał Kwiatek, Joanna Majka, Halina Wiśniewska   +3 more
openalex   +1 more source

The genome of the medieval Black Death agent (extended abstract)

, 2013
The genome of a 650 year old Yersinia pestis bacteria, responsible for the medieval Black Death, was recently sequenced and assembled into 2,105 contigs from the main chromosome.
Chauve, Cedric, Rajaraman, Ashok, Tannier, Eric   +2 more
core   +1 more source

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Unraveling the interplay of DNA methylation and chromosome organization. [PDF]

Biochem Soc Trans
Pei Y, Li G.
europepmc   +1 more source

Chromosome organization by Structural Maintenance of Chromosomes complexes in C. elegans.

Sinem Erkan, Kalyan Pradip Ghadage, Peter Meister   +2 more
openalex   +1 more source

Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity.

, 1990
M. Cubbage, Adisak Suwanichkul, D.R. Powell   +2 more
openalex   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Biophysics of protein–DNA interactions and chromosome organization

, 2014
John F. Marko
openalex   +2 more sources

Genomic Organization of the Mouse src Gene. Sequencing of src Introns Revealed a New Chromosome 2 Microsatellite Marker [PDF]

, 2002
Vladimı́r Fučı́k, Jiřı́ Beran, Zbyněk Černý, J Mácha, Jiřı́ Jonák   +4 more
openalex   +1 more source