Results 211 to 220 of about 405,684 (326)

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Time‐Efficient and Informatic‐Skill‐Light Gap‐Filling for Telomere‐to‐Telomere Genome Assembly

Advanced Science, EarlyView.
The paper introduces a novel auxiliary software toolbox GapSuite, consisting of two tools Gap‐Aid and Gap‐Graph, which guides users to fill gaps in chromosome‐level genome assembly using sequence‐extension‐based and assembly‐graph‐based strategies. The two tools enable users with limited informatics expertise to efficiently complete gap‐filling on ...
Dong Xu, Xianjia Zhao, Lianguang Shang, Shaolong Tian, Yanchun Li, Huaming Wen, Qiang Xu, Dongxi Li, Weihua Pan   +8 more
wiley   +1 more source

Spatio-temporal organization of the E. coli chromosome from base to cellular length scales

Sonya Royzenblat, Lydia Freddolino
openalex   +2 more sources

CENP-V is required for centromere organization, chromosome alignment and cytokinesis [PDF]

, 2008
Ana Tadeu, Susana A. Ribeiro, Josiah Johnston, I. Goldberg, Dietlind L. Gerloff, William C. Earnshaw   +5 more
openalex   +1 more source

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source

Emergence of supercoiling-mediated regulatory networks through the evolution of bacterial chromosome organization. [PDF]

PLoS Comput Biol
Grohens T, Meyer S, Beslon G.
europepmc   +1 more source

Recruitment of MRE-11 to complex DNA damage is modulated by meiosis-specific chromosome organization. [PDF]

Mutat Res, 2021
Harrell K, Day M, Smolikove S.
europepmc   +1 more source

Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny [PDF]

, 2018
Laurence Berry, Chun‐Ti Chen, María E. Francia, Amandine Guérin, Arnault Graindorge, Jean‐Michel Saliou, Maurane Grandmougin, Sharon Wein, Chérine Bechara, Juliette Morlon‐Guyot, Yann Bordat, Marc‐Jan Gubbels, Maryse Lebrun, Jean‐François Dubremetz, Wassim Daher   +14 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

In Vivo Silencing of Genes Coding for dTip60 Chromatin Remodeling Complex Subunits Affects Polytene Chromosome Organization and Proper Development in Drosophila melanogaster. [PDF]

Int J Mol Sci, 2021
Prozzillo Y, Cuticone S, Ferreri D, Fattorini G, Messina G, Dimitri P.   +5 more
europepmc   +1 more source