Results 231 to 240 of about 405,684 (326)

Chromosomal Organization and Sequence Diversity of Genes Encoding Lachrymatory Factor Synthase in Allium cepa L. [PDF]

, 2012
Noriya Masamura, John McCallum, Ludmila Khrustaleva, Fernand Kenel, Meeghan Pither-Joyce, Jinji Shono, Go Suzuki, Yasuhiko Mukai, Naoki Yamauchi, Masayoshi Shigyo   +9 more
openalex   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Chromosome organization shapes replisome dynamics in Caulobacter crescentus. [PDF]

Nat Commun
Zhang C, Joseph AM, Casini L, Collier J, Badrinarayanan A, Manley S.   +5 more
europepmc   +1 more source

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

Stability and gene strand bias of lambda prophages and chromosome organization in Escherichia coli. [PDF]

mBio
Li X, Gallardo O, August E, Dassa B, Court DL, Stavans J, Arbel-Goren R.   +6 more
europepmc   +1 more source

Braiding topology and the energy landscape of chromosome organization proteins. [PDF]

Proc Natl Acad Sci U S A, 2020
Krepel D, Davtyan A, Schafer NP, Wolynes PG, Onuchic JN.   +4 more
europepmc   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Tet-mediated DNA methylation dynamics affect chromosome organization. [PDF]

Nucleic Acids Res
Tian H, Luan P, Liu Y, Li G.
europepmc   +1 more source

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum. [PDF]

Nat Commun, 2020
Böhm K, Giacomelli G, Schmidt A, Imhof A, Koszul R, Marbouty M, Bramkamp M.   +6 more
europepmc   +1 more source