Results 291 to 300 of about 1,033,685 (362)

A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis

Brain Pathology, EarlyView.
circRMST (hsa_circ_0099634) is by far the most abundant isoform from the RMST locus. It is highly expressed in cancer cells throughout ependymoma patient samples and is located in the cytoplasm. circRMST knockdown causes cell cycle arrest and induces differentiation, and it is a marker for poor prognosis. The figure is made using BioRender.
Ulvi Ahmadov, Charlotte W. Udengaard, Stine M. Vissing, Silke D. Nielsen, Kim‐Gwendolyn Dietrich, Benedicte Parm Ulhøi, Lasse S. Kristensen   +6 more
wiley   +1 more source

ANAPHASE-PROMOTING COMPLEX/CYCLOSOME coactivators maintain AURORA 1 kinase homeostasis during meiotic chromosome segregation. [PDF]

Plant Cell
Xu J, Zhou L, Chen K, Huang R, Niu B, Ye J, Ma H, Copenhaver GP, Wang Y.   +8 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Role of noncanonical histone H2A variant, H2A.Z, to maintain proper centromeric transcription and chromosome segregation. [PDF]

J Biol Chem
Akter M, Lyu X, Lu J, Wang X, Phonesavanh T, Wang H, Yu H, Kang J.   +7 more
europepmc   +1 more source

A century of theories of balancing selection

Biological Reviews, EarlyView.
ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka, Martyna K. Zwoinska, Debora Goedert, Hanna Kokko, Xiang‐Yi Li Richter, Iain R. Moodie, Sofie Nilén, Colin Olito, Erik I. Svensson, Peter Czuppon, Tim Connallon   +10 more
wiley   +1 more source

An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity. [PDF]

Cell Rep
Kucharski TJ, Vlasac IM, Lyalina T, Higgs MR, Christensen BC, Bechstedt S, Compton DA.   +6 more
europepmc   +1 more source

The spindle checkpoint and chromosome segregation in meiosis

The FEBS Journal, 2015
G. Gorbsky
semanticscholar   +1 more source

MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe

Cancer Science, EarlyView.
MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang, Ziwei Fu, Chuan Xiong, Jing Zhang, Qiang Luo   +4 more
wiley   +1 more source

Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation

Dias Maia Henriques AM, Davies T, Dmitrieff S, Minc N, Canman JC, Dumont J, Maton G.   +6 more
europepmc   +1 more source

The drosophila ord gene, sister-chomatid cohesion, and chromosome segregation

, 1994
W Y Miyazaki
openalex   +1 more source