Results 291 to 300 of about 191,348 (320)

Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression

The FEBS Journal, EarlyView.
Genes repressed by the Polycomb system display greater chromatin folding compared to ‘regular’ inactive genes. The associated chromatin compaction, driven by PRC1‐H3K27me3 interactions, is modest and dynamic. This questions traditional models where Polycomb proteins repress transcription by sheltering genes from transcriptional activators.
Ludvig Lizana, Yuri B. Schwartz
wiley   +1 more source

Biophysics of chromosome segregation: New evidence for a pushing body model of chromosome segregation

, 2018
Che‐Hang Yu
openalex   +1 more source

Search for chromosomal instability aiding variants reveal naturally occurring kinetochore gene variants that perturb chromosome segregation

Asifa Islam, Janeth Catalina Manjarrez-González, Xinhong Song, Trupti Gore, Viji M. Draviam   +4 more
openalex   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes. [PDF]

J Cell Biol
Ballmer D, Lou HJ, Ishii M, Turk BE, Akiyoshi B.   +4 more
europepmc   +1 more source

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, EarlyView.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source

CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation. [PDF]

Life Sci Alliance
Kong W, Hara M, Tokunaga Y, Okumura K, Hirano Y, Miao J, Takenoshita Y, Hashimoto M, Sasaki H, Fujimori T, Wakabayashi Y, Fukagawa T.   +11 more
europepmc   +1 more source

Lysine demethylase 4A: from chromatin to centrosomes

The FEBS Journal, EarlyView.
The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome.
Anushka Sharma, Ruth M. Kearney, Ciaran G. Morrison   +2 more
wiley   +1 more source

Inhibitor of Chromosome Segregation in <i>Pseudomonas aeruginosa</i> from Fungal Extracts. [PDF]

ACS Chem Biol
Zhao H, Peramuna T, Ajmal S, Wendt KL, Petrushenko ZM, Premachandra K, Cichewicz RH, Rybenkov VV.   +7 more
europepmc   +1 more source

The role of DNA topoisomerase 1α (AtTOP1α) in regulating arabidopsis meiotic recombination and chromosome segregation. [PDF]

PeerJ
Elesawi IE, Hashem AM, Yao L, Maher M, Hassanin AA, Abd El-Moneim D, Safhi FA, Al Aboud NM, Alshamrani SM, Shehata WF, Chunli C.   +10 more
europepmc   +1 more source