Results 221 to 230 of about 1,037,337 (302)

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

EASY-C: Extraction and Analysis of Small Yeast Chromosomes-A rapid and universal platform for recovering artificial mini-chromosomes from synthetic Sc2.0 yeast and large plasmids from <i>Saccharomyces cerevisiae</i> and nonconventional yeast species. [PDF]

Synth Biol (Oxf)
Swidah R, Monti M, Delneri D.
europepmc   +1 more source

Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics

mLife, EarlyView.
Abstract Persistent bacteria subpopulations showing multidrug tolerance pose significant challenges to antibiotic therapy. While the HipBA toxin–antitoxin (TA) system is known to play a role in persister formation, existing studies predominantly focus on its kinase activity and intracellular regulatory pathways, with limited attention to the ...
Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang   +4 more
wiley   +1 more source

Karyotypic diversity in the Gobiidae: A comparative analysis of two Atlantic species. [PDF]

Comp Cytogenet
de Lima-Filho PA, da Costa GWWF, da Silva SAS, Molina WF.   +3 more
europepmc   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

SmallBARNA 2026: a kingdom-wide bacterial sRNA resource. [PDF]

Nucleic Acids Res
Rishik S, Molano LAG, Khalid SM, Babalashvili T, Hasanah FN, Rahman MM, Hirsch P, Grandke F, Hoffmann ES, Wolff TW, Schmartz GP, Keller A.   +11 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Plasmids as persistent genetic reservoirs of bacterial defense systems in wastewater treatment. [PDF]

Microbiome
Zheng H, Payne L, He W, Mestre MR, Yang L, Dechesne A, Pinilla-Redondo R, Nesme J, Sørensen SJ.   +8 more
europepmc   +1 more source

One Yeast, Sixteen Synthetic Chromosomes, Infinite Possibilities. [PDF]

Yeast
Archer E, Walker RSK, Erpf PE, Paulsen IT, Pretorius IS.   +4 more
europepmc   +1 more source

Sex chromosome-targeted Cas9 knock-in and functional validation in chicken primordial germ cells. [PDF]

Poult Sci
Jung KM, Mony SI, Chen PR, Lee K, Lee HJ.   +4 more
europepmc   +1 more source