Results 31 to 40 of about 351,075 (215)
A role for Separase in telomere protection [PDF]
, 2016 Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity and are assembled independently of the sequence. Fly telomeres are protected by the terminin complex that localizes and functions exclusively
Bosso, Giuseppe +9 more
core +1 more source
Reporting Unwelcome Unanticipated Findings of Diagnostic Genomic Studies
Voices in Bioethics, 2014 The introduction of comparative genomic hybridization has revolutionized clinical genetics. It is used as a routine approach to the workup of developmental delays and multiple malformations.1-3 By subdividing chromosomes into their submicroscopic ...
Brian James Hanrahan, Robert Roger Lebel
doaj +1 more source
The Gender Gap in Pharmaceutical Research
Voices in Bioethics, 2018 “I did what?!” That’s the question more than 1,350 people asked[*1] when reporting adverse effects of Ambien [1]. The accounts became increasingly bizarre – sleep-eating, sleep-walking, sleep-driving.
Elisabeth Armstrong
doaj +1 more source
The architecture of chicken chromosome territories changes during differentiation [PDF]
, 2004 BACKGROUND: Between cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory.
Bonifer, C. +7 more
core +4 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Spectral Analysis of Guanine and Cytosine Fluctuations of Mouse Genomic DNA
, 2004 We study global fluctuations of the guanine and cytosine base content (GC%) in mouse genomic DNA using spectral analyses. Power spectra S(f) of GC% fluctuations in all nineteen autosomal and two sex chromosomes are observed to have the universal ...
Bernardi G. +15 more
core +1 more source
Detection of fluorescence in situ hybridization on human metaphase chromosomes by near-field scanning optical microscopy [PDF]
, 1995 Fluorescence in situ hybridization signals on human metaphase chromosomes are detected by a near-field scanning optical microscope. This makes it possible to localize and identify several fluorescently labeled genomic DNA fragments on a single ...
Jalocha, A. +5 more
core +3 more sources