Results 161 to 170 of about 256,500 (196)

When Genetics Meet Hormones: Infertility and Normogonadotropic Hypogonadism From Robertsonian Translocation (14;21). [PDF]

Cureus
Gonzalez-Carranza HR, Saucedo-Conrado N, Reyes-Vallejo LA.   +2 more
europepmc   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

49, XXXYY: Parental Origin, Occurrence, and Clinical Phenotypes. [PDF]

Genet Res (Camb)
Du Y, Liao L, Wei X, Ma Y, Shi M, Li C, Liu J, Lin W, Zeng H, Chen S, Gui B.   +10 more
europepmc   +1 more source

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, EarlyView.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Telomere-to-telomere genome assembly of the Dipteran Bactrocera dorsalis from a single individual. [PDF]

Nat Commun
Liu W, Lin Q, Wang Q, Liu W, Jia J, Zhang J, Yang L, Lu Y, Cui P, Wang G.   +9 more
europepmc   +1 more source

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

Single sperm karyotyping of testicular sperm in non-obstructive and obstructive azoospermia using next generation sequencing. [PDF]

PLoS One
Sueyoshi S, Ijuin A, Ueno H, Miyakoshi A, Hamada H, Toda M, Tsuchiya N, Tanoshima M, Kurumizaka M, Saito M, Oike Y, Takeshima K, Takeshima T, Kuroda S, Yumura Y, Saito S, Asano R, Mizushima T, Miyagi E, Sakakibara H, Kurahashi H, Yanagihara A, Murase M, Hayama T.   +23 more
europepmc   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Applications and challenges of Drosophila melanogaster as a laboratory model in human cancer research: a narrative review. [PDF]

Discov Oncol
Abdullateef R, Ibekwe JP, Oyoyo H, Ogbodo S.   +3 more
europepmc   +1 more source

Generation of alphoid DNA probes for fluorescence in situ hybridization using the polymerase chain reaction [PDF]

, 1994
Cremer, Thomas, Dunham, Ian, Featherstone, Terry, Lengauer, Christoph   +3 more
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