Results 31 to 40 of about 256,500 (196)

Detection of fluorescence in situ hybridization on human metaphase chromosomes by near-field scanning optical microscopy [PDF]

, 1995
Fluorescence in situ hybridization signals o­n human metaphase chromosomes are detected by a near-field scanning optical microscope. This makes it possible to localize and identify several fluorescently labeled genomic DNA fragments o­n a single ...
Jalocha, A., Jalocha, A., Moers, M.H.P., Moers, M.H.P., Ruiter, A.G.T., van Hulst, N.F.   +5 more
core   +3 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21

, 2004
An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb.
Aaltonen, Aaltonen, Arques, Baldi, Bernardi, Bernardi, Borodovsky, Burge, Clay, Clay, Clay, Dirk Holste, Fickett, Fukushima, Golfier, Grosse, Guigo, Hattori, Herzel, Holste, Konopka, Larsen, Li, Li, Li, Macaya, McKusick, Nagamine, Nekrutenko, Oliver, Oliver, Pavlícek, Pizzi, Saccone, Shiba, Shulman, Smit, Staden, Tiwari, Tomita, Trifonov, Trifonov, Wentian Li, Widom, Zhurkin   +44 more
core   +2 more sources

Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization [PDF]

, 1990
A new strategy for analyzing chromosomal evolution in primates is presented using chromosomal in situ suppression (CISS) hybridization. Biotin-labeled DNA libraries from flow-sorted human chromosomes are hybridized to chromosome preparations of ...
Anna Jauch, Bickmore, Cremer, Cremer, de Grouchy, Dutrillaux, Holmquist, Johannes Wienberg, Lalley, Lichter, Lichter, Lichter, O'Brien, Ohno, Pinkel, Roscoe Stanyon, Seuánez, Stanyon, Thomas Cremer, Van Dilla, Weber, Wienberg, Yunis   +22 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Phylogenetic inferences of Atelinae (Platyrrhini) based on multi-directional chromosome painting in Brachyteles arachnoides, Ateles paniscus paniscus and Ateles b. marginatus [PDF]

, 2005
We performed multi-directional chromosome painting in a comparative cytogenetic study of the three Atelinae species Brachyteles arachnoides, Ateles paniscus paniscus and Ateles belzebuth marginatus, in order to reconstruct phylogenetic relationships ...
C. Nagamachi, Collins AC, Consigliere S, Dutrillaux B, Dutrillaux B, E.H.C. de Oliveira, Garcia F, Garcia F, I.J. Sbalqueiro, J.C. Pieczarka, Kay RF, Kellogg R, Kunkel LM, M. Neusser, Muller S, Pequignot E, Pieczarka JC, S. Müller   +17 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The Discovery of XY Sex Chromosomes in a \u3cem\u3eBoa\u3c/em\u3e and \u3cem\u3ePython\u3c/em\u3e [PDF]

, 2017
For over 50 years, biologists have accepted that all extant snakes share the same ZW sex chromosomes derived from a common ancestor [1, 2, 3], with different species exhibiting sex chromosomes at varying stages of differentiation.
Banks, Jason L., Booth, Warren, Card, Daren C., Castoe, Todd A., Gamble, Tony, Nielsen, Stuart V., Schield, Drew R., Schuett, Gordon W.   +7 more
core   +1 more source

Statistical analysis of simple repeats in the human genome

, 2005
The human genome contains repetitive DNA at different level of sequence length, number and dispersion. Highly repetitive DNA is particularly rich in homo-- and di--nucleotide repeats, while middle repetitive DNA is rich of families of interspersed ...
Batzer, Bhattacharyya, Bois, Brukner, Chingfer, Coté, Deepali, Deininger, Deininger, Dermitazakis, Dieringer, Englander, Eyre-Walker, Force, Fransz, Fryxell, Glusman, Han, Herzel, Holste, Iyer, Johanning, Kazazian, Lai, Li, Lillo, Lio, Lynch, Lynch, Lynch, Mantegna, Nelson, Roy-Engel, Scott, Umar, Wagner, Wagner, Wassermann, Weiner   +38 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source