Results 91 to 100 of about 112,898 (258)

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Systematic analysis of genomic alterations in prostate cancer

, 2011
PhDProstate cancer is the most common male cancer in Western countries. The genetic mechanism underlying its initiation and progression is still unclear.
Mao, Xueying
core  

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms

, 2009
A genomewide linkage scan was carried out in eight clinical samples of informative schizophrenia families. After all quality control checks, the analysis of 707 European-ancestry families included 1615 affected and 1602 unaffected genotyped individuals ...
D Walsh, Gejman, P. V., D F Levinson, Alexander, M., Ribble, R, Mallet, J., Wormley, B., Godard, S, O'Neill, A., Dikeos, D., Alexander, M, Owen, Michael John, F B Lerer, Holmans, PA, Wormley, B, O'Donovan, MC, Liang, KY, R R Crowe, Norton, N., Jay, M., Nertney, D., Silverman, J. M., Levinson, D. F., Mowry, Bryan, Sanders, A. R., Nestadt, G., P A Holmans, Walsh, D., Pulver, A. E., V K Lasseter, Laurent, C, Kendler, K. S., A O'Neill, A E Pulver, C Laurent, Holmans, Peter Alan, G Nestadt, M J Owen, M Alexander, Holmans, P. A., O'Donovan, Michael Conlon, D B Wildenauer, Albus, M., O'Neill, Anthony, Norton, N, P V Gejman, Gejman, PV, Wildenauer, DB, M Albus, Maier, W, Williams, N. M., Nestadt, G, Schwab, SG, G Papadimitriou, Nertney, D, Papadimitriou, G, Lasseter, V. K., D Nertney, Liang, K. Y., Lerer, F. B., Lasseter, VK, O'Donovan, M. C., Duan, J., K S Kendler, Mallet, J, O'Neill, A, N M Williams, J Duan, Mowry, B. J., Duan, J, B Riley, D Dikeos, Owen, M. J., M C O'Donovan, B J Mowry, J Mallet, Owen, MJ, Laurent, C., Norton, Nadine, Jay, M, Crowe, R. R., B Wormley, Maier, W., Albus, M, Walsh, D, R Ribble, Schwab, S. G., S G Schwab, S Godard, N Norton, W Maier, Papadimitriou, G., M Jay, Riley, B, Williams, Nigel Melville, Kendler, KS, Williams, NM, A R Sanders, Lerer, FB, Riley, B., K Y Liang, Pulver, AE, Sanders, AR, Godard, S., Ribble, R., Wildenauer, D. B., J M Silverman   +106 more
core   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese.

Human Molecular Genetics, 2001
K. Sakai, S. Shirasawa, N. Ishikawa, Kunihiko Ito, H. Tamai, K. Kuma, Takashi Akamizu, Masako Tanimura, Koichi Furugaki, Ken Yamamoto, T. Sasazuki   +10 more
semanticscholar   +1 more source

Clinical molecular genetics in the UK c.1975-c.2000

, 2014
seminar transcriptChaired by Professor Martin Bobrow and introduced by Professor Bob Williamson, this Witness Seminar included geneticists from a broad range of research and clinical specialities.
Jones, EM, Tansey, EM
core  

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source