Results 181 to 190 of about 163,352 (213)

Improving spliced alignment by modeling splice sites with deep learning. [PDF]

Algorithms Mol Biol
Yang S, Huang N, Li H.
europepmc   +1 more source

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, EarlyView.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Cell line-matched reference enables high-precision functional genomics. [PDF]

Nat Commun
Corda L, Volpe E, Dallali H, Di Tommaso E, Colantoni A, Guarracino A, Chittoor SS, Capulli M, Tassone E, Giunta S.   +9 more
europepmc   +1 more source

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

Insights into natural neocentromere evolution from a cattle T2T X chromosome. [PDF]

Nat Commun
Pineda PS, MacPhillamy C, Ren Y, Chen T, Zhong L, Adelson DL, Dessaix C, Perez-Silva J, Haggerty L, Martin FJ, Bottema CDK, Pitchford WS, Rosen BD, Smith TPL, Low WY.   +14 more
europepmc   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

The genetics of extrinsic postzygotic selection in a migratory divide between subspecies of the Swainson's thrush. [PDF]

Nat Commun
Justen HC, Blain SA, Delmore KE.
europepmc   +1 more source

Repetitive DNAs and Karyotype Evolution in Phyllostomid Bats (Chiroptera: Phyllostomidae). [PDF]

Biomolecules
Deon GA, Ezaz T, Stornioli JHF, Dos Santos RZ, Gomes AJB, Setti PG, de Oliveira EHC, Porto-Foresti F, Utsunomia R, Liehr T, Cioffi MB.   +10 more
europepmc   +1 more source

The regulatory mechanisms controlling meiotic cross-over patterning in plants. [PDF]

Biochem Soc Trans
Xu W, Lian Q, Li M, Copenhaver GP, Wang Y.   +4 more
europepmc   +1 more source

Direct detection of meiotic recombination events in the highly heterozygous amphioxus genome. [PDF]

Adv Biotechnol (Singap)
Tao L, Xue J, Cao J, Li G, Li C.
europepmc   +1 more source