Results 181 to 190 of about 14,890,055 (213)

CRISPR‐Scan: Cas13a Mismatch Tolerance Enabled Ultra‐Multiplexed Detection of Same‐Site Indels in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Accurately detecting diverse same‐locus insertions or deletions (indels) remains challenging. This study reveals the mismatch‐tolerance profile of LwaCas13a and establishes CRISPR‐Scan, which uses a single crRNA to detect multiple same‐locus indels. The one‐pot assay detects nucleophosmin 1 (NPM1) mutant allele frequencies down to 0.01%, agrees with ...
Linlin Bai, Bei Wang, Mingmin Shi, Dianwei Liu, Huimin Ji, Ting Wang, Ziwei Wang, Kaiming Guo, Xinyang Dou, Chunyan Qian, Fang Zhang, Yongming Wang, Hongju Mao, Rui Wang   +13 more
wiley   +1 more source

ONYX: an alignment-free biological sex inference from high-throughput sequencing data. [PDF]

Front Bioinform
Ishiya K.
europepmc   +1 more source

Human acrocentric chromosome short-arm de novo mutation and recombination. [PDF]

Cell
Lin J, Mastrorosa FK, Noyes MD, Yoo D, Rhie A, Porubsky D, Hoekzema K, Munson KM, Koundinya N, Watkins WS, Jorde LB, Quinlan AR, Neklason DW, Phillippy AM, Eichler EE.   +14 more
europepmc   +1 more source

Genetic profiling enhances cystic fibrosis prenatal diagnosis. [PDF]

Sci Rep
Hosseini Nami A, Kabiri M, Zafarghandi Motlagh F, Zeinali R, Karimi A, Aslani S, Zeinali S.   +6 more
europepmc   +1 more source

LAWS-HiC: A Locally Adaptive Weighting and Screening (LAWS) Approach to Improve Detection of Long-Range Chromatin Interactions from Hi-C Data. [PDF]

Methods Protoc
Zhou L, Chen C, Zhao JZ, Hu M, Li Y.
europepmc   +1 more source

Unambiguous chromosome identification by multicolour fluorescence in situ hybridisation reveals the genome organisation and evolution of sheepgrass (Leymus chinensis). [PDF]

BMC Plant Biol
Sun M, Hu S, Li T, Lv N, Han J, Li Y, Lu J, Wang Z, He T, Sun M, Qi Z, Xiong Z, Wu L.   +12 more
europepmc   +1 more source

The Multifunctional SMC5/6 Complex in Genome Stability, Antiviral Restriction, and Human Disease. [PDF]

Curr Issues Mol Biol
Zhang Y, Lai W, Song J, Qiu C, Yan R, Zhao Q, Yu Y.   +6 more
europepmc   +1 more source

CATE 12

CATE 12, CATE 12
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