Results 111 to 120 of about 13,460,922 (217)

MGA: a tool for haplotype-mixed assembly of long and accurate reads. [PDF]

Genome Biol
Zhang Z, Fedarko MW, Bankevich A, Pevzner PA.   +3 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Baseline Frequency of Chromosomal Aberrations in Control Donors: A Significant Value for Population Monitoring During the Development of the Nuclear Energy Industry-Polish Dataset. [PDF]

Toxics
Sommer S, Buraczewska I, Korzeniowska-Sobczuk A, Sikorska K.   +3 more
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Topological mixing and irreversibility in animal chromosome evolution. [PDF]

Sci Adv
Schultz DT, Blümel A, Destanović D, Sarigol F, Simakov O.   +4 more
europepmc   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

The complete sequence of the silkworm W chromosome uncovers its rapid evolution by large-scale duplications/deletions and translocation of W-linked genes. [PDF]

G3 (Bethesda)
Li W, Abe H, Chen Y, Liu J, Wang Y, Ajimura M, Li S, Xiao Y, Guo H, Wu J, Xu Y, Yang X, Yang X, Hao S, He Q, Fujii T, Sahara K, Yoshido A, Takehana Y, Naruse K, Arunkumar KP, Goldsmith MR, Smagghe G, Marec F, Xia Q, Mita K.   +25 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

An evolutionarily conserved early replicatig segment on the sex chromosomes of man and great apes [PDF]

, 1986
Weber, Bernhard, Wiesner, Henning, Schempp, Werner   +2 more
core   +1 more source

Automated karyotyping and structural anomaly detection through a hybrid multi-stage deep learning framework integrating chromosome detection, pairwise classification, and autoencoder-based analysis. [PDF]

Sci Rep
Rosas-Alatriste C, Rodríguez-Rodríguez NO, Argüelles-Cruz AJ, Rosas-Cabral A, Yáñez-Márquez C, Alarcón-Paredes A.   +5 more
europepmc   +1 more source