Results 181 to 190 of about 158,291 (213)

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF. [PDF]

Sci Adv
Henikoff S, Henikoff JG.
europepmc   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Comparative genomics of Borrelia lusitaniae. [PDF]

G3 (Bethesda)
Lopes de Carvalho I, Núncio MS, Norte AC, Mongodin EF, Luft BJ, Schutzer SE, Yang X, Fraser CM, Hepner S, Fingerle V, Margos G, Morgan R, Akther S, Qiu W, Casjens SR.   +14 more
europepmc   +1 more source

Boundary-associated propagation of a processed pseudogene dissects pre-existing limitations of genome annotation in the T2T era. [PDF]

Mob DNA
Lee MG.
europepmc   +1 more source

Reconstitution of DNA fragments on HAC/MAC via the fragment-assembly system. [PDF]

Sci Rep
Suzuki T, Yamakawa M, Sasaki S, Okada A, Kazuki K, Abe S, Nara S, Su'etsugu M, Hara T, Kazuki Y.   +9 more
europepmc   +1 more source

Extrachromosomal circular DNA: a potential clinical therapeutic target in malignant tumors. [PDF]

Cell Mol Biol Lett
Zhang H, Zhuo E, Li M, Feng J, Shi X, Sun X.   +5 more
europepmc   +1 more source

NyxBind: enhancing deep neural representations for transcription factor binding site prediction via contrastive learning. [PDF]

Brief Bioinform
Yang X, Xiao Q, Xu Y, Yang J, Hou Y, Long W, Huang M, Zhang Y.   +7 more
europepmc   +1 more source

Cell line-matched reference enables high-precision functional genomics. [PDF]

Nat Commun
Corda L, Volpe E, Dallali H, Di Tommaso E, Colantoni A, Guarracino A, Chittoor SS, Capulli M, Tassone E, Giunta S.   +9 more
europepmc   +1 more source