Results 61 to 70 of about 76,435 (221)

A Genomewide Screen for Autism Susceptibility Loci

, 2001
We report the analysis of 335 microsatellite markers genotyped in 110 multiplex families with autism. All families include at least two “affected” siblings, at least one of whom has autism; the remaining affected sibs carry diagnoses of either Asperger ...
Autism Genetic Resource Exchange Consortium, the, Patrick Magnussen, Catherine Lord, Gilliam, T. Conrad, Liu, Jianjun, T. Conrad Gilliam, Geschwind, Daniel, Piero Pavone, the Autism Genetic Resource Exchange Consortium, Iversen, Portia, Lord, Catherine, Daniel Geschwind, Jianjun Liu, Portia Iversen, Parano, Enrico, Nyholt, Dale R., Dale R. Nyholt, Magnussen, Patrick, Ott, Jurg, Hoh, Josephine, Enrico Parano, Josephine Hoh, Pavone, Piero, Jurg Ott   +23 more
core   +2 more sources

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Homologous recombination, sister chromatid cohesion, and chromosome condensation in mammalian meiosis

, 2002
In the life cycle of sexually reproducing eukaryotes, haploid and diploid generations of cells alternate. Two types of cell division occur in such a life cycle: mitosis and meiosis. They are compared in chapter 1 .
Eijpe, M.
core  

Analysis of the role of the X/Y homologous gene family Xmr/Sly in murine spermiogenesis [PDF]

, 2009
Spermatogenesis is a complex, continuous developmental process that involves the formation of highly differentiated haploid sperm from diploid spermatogonial stem cells.
Reynard, L N, Reynard, L.N.
core  

Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26

, 2005
Endometriosis is a common gynecological disease that affects up to 10% of women in their reproductive years. It causes pelvic pain, severe dysmenorrhea, and subfertility.
O'Connor D, T., Barlow, D. H., Dawson, G., Treloar, Susan A., Kennedy, S. H., Montgomery, Grant W., Bennett, Simon T., Bennett, S. T., Weeks, D. E., Ewen-White, Kelly R., Montgomery, GW, Carey, A, Wicks, J, Ewen-White, KR, Martin, NG, Mackay, I. J., Ewen-White, K. R., Nyholt, D. R., Carey, A., Barlow, DH, Smith, Vicki, Weeks, DE, Martin, Nicholas G., Kennedy, Stephen, Montgomery, G. W., Bahlo, M, Wicks, Jacqueline, O’Connor, Daniel T., Barlow, David H., Treloar, SA, Dawson, Gary, Duffy, David L., Duffy, D. L., Nyholt, Dale R., Smith, V., Treloar, S. A., Kennedy, SH, Wicks, J., Smith, V, Weeks, Daniel E., Bahlo, M., Bennett, ST, Martin, N. G., Dawson, G, O'Connor, DT, Bahlo, Melanie, Mackay, Ian J., Carey, Alisoun, Nyholt, DR, Kennedy, Stephen H., Duffy, DL, Mackay, IJ   +51 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

A comprehensive comparison of comparative RNA structure prediction approaches

, 2004
Gardner PP, Giegerich R. A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics. 2004;5(1): 140.Background: An increasing number of researchers have released novel RNA structure analysis and prediction ...
Giegerich, R., Gardner, Paul P., Gardner, P. P., Paul P Gardner, Robert Giegerich, Giegerich, Robert, Giegerich Robert, Gardner Paul P   +7 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source