Results 61 to 70 of about 71,445,035 (215)

Bird-like sex chromosomes of platypus imply recent origin of mammal sex chromosomes [PDF]

, 2008
Copyright © 2008 by Cold Spring Harbor Laboratory PressIn therian mammals (placentals and marsupials), sex is determined by an XX female: XY male system, in which a gene (SRY) on the Y affects male determination. There is no equivalent in other amniotes,
Whittington, C., Veyrunes, Frederick, Ferguson-Smith, Malcolm, Waters, Paul, Grutzner, F., Warren, Wes, Ferguson-Smith, M., Graves, J., Rens, W., Whittington, Camilla, Kremitzki, Colin, Graves, Tina, Warren, W., Deakin, J., Schatzkamer, K., Veyrunes, Frédéric, Waters, P., Deakin, Janine; id_orcid, Alsop, A., Deakin, Janine E., Ferguson-Smith, Malcolm A., Marshall Graves, Jennifer, McMillan, D., Whittington, Camilla M., Marshall Graves, Jennifer A., Alsop, Amber E., Schatzkamer, Kyriena, Graves, T., McMillan, Daniel, Veyrunes, F., Miethke, P., Waters, Paul D., Miethke, Pat, Grützner, Frank, Kremitzki, Colin L., Kremitzki, C., Alsop, Amber, Rens, Willem   +37 more
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Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Chromosome assignment of two cloned DNA probes hybridizing predominantly to human sex chromosomes [PDF]

, 1984
In situ hybridization experiments were carried out with two clones, YACG 35 and 2.8, which had been selected from two genomic libraries strongly enriched for the human Y chromosome.
Back, W., Cremer, Thomas, Rappold, Gudrun A., Cremer, Christoph, Bogenberger, J., Cooke, H. J.   +5 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

45S rDNA methylation states of the two pair chromosomes of 65 cells at different stages.

, 2013
Type I: In the two pairs of chromosomes, the 45S rDNA of one pair were unmethylated and the other were methylated. Type II: In the two pairs of chromosomes, the 45S rDNA of one pair were methylated in telomeric region and the other were methylated.
Yong Zhou (23772), Mingliang Zhang (104816), Rui Guo (134395), Guoxin Shi (503329), Chao Xue (503328), Zhiyun Gong (456588)   +5 more
core   +1 more source

Thermodynamic pathways to genome spatial organization in the cell nucleus [PDF]

, 2009
The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex ...
A. Prisco, Prisco, Antonella, Nicodemi, Mario, Nicodemi M, Prisco A   +4 more
core   +1 more source

Development of a Biological Dosimeter for Translocation Scoring Based on Two-Color Fluorescence in Situ Hybridization of Chromosome Subsets [PDF]

, 1992
Recently fluorescence in situ hybridization protocols have been developed which allow the paining of individual chromosomes using DNA-libraries from sorted human chromosomes.
Cremer, Thomas, Popp, Susanne
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Sex Chromosomes

, 1967
Sex Chromosomes focuses on the study of sex chromosomes, including human chromosomal abnormalities, behavior and characteristics of chromosomes, and cell division.
Mittwoch, Ursula
core  

Disease-associated patterns of disomic chromosomes in hyperhaploid neoplasms.

, 2012
The chromosome number of human tumors varies widely, from near-haploidy to more than decaploidy. Overt hyperhaploid (24-34 chromosomes) tumors constitute a small minority (0.2-0.3% of cytogenetically investigated lesions), but occur in many different ...
Johansson, Bertil, Johansson, Bertil,, Mitelman, Felix,, Mandahl, Nils,, Mandahl, Nils, Mertens, Fredrik, Mertens, Fredrik,, Lund University., Mitelman, Felix   +8 more
core   +1 more source