Results 61 to 70 of about 68,587 (225)

A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solution

, 2019
Guanine tracts of human telomeric DNA sequences are known to fold into eight different four-stranded structures that vary by the conformation of guanine nucleotides arranged in the stack of G-tetrads in their core and by different kinds and orders of ...
Zhou, B, Kwan Lo, P, Tang, BZ, Kuryavyi, V, Feng, R, Hong, Y, Zhu, G, Xu, N, Yan Tam, D, You, Y, Liu, C, Miao, H, Shi, X, Geng, Y   +13 more
core   +1 more source

Role of histone methylation in paternal transmission of epigenetic information [PDF]

, 2010
During the development of multi-cellular organisms, one genome gives rise to multiple differentiated cell types. This is achieved by sequence specific transcription factors and different epigenetic mechanisms, which collaborate in reading the genetic ...
Brykczynska, Urszula
core   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

A Natural System of Chromosome Transfer in Yersinia pseudotuberculosis [PDF]

, 2012
The High Pathogenicity Island of Yersinia pseudotuberculosis IP32637 was previously shown to be horizontally transferable as part of a large chromosomal segment.
Biliana Lesic, Didier Mazel (158958), Magaly Ducos-Galand, Didier Mazel, Magaly Ducos-Galand (178854), Marie-Christine Prévost, Prévost Marie-Christine, Huon Christèle, Marie-Laure Rosso, Ducos-Galand, Magaly, Zouine, Mohamed, Marie-Christine Prévost (2280838), Christèle Huon (178859), Marie-Laure Rosso (178864), Carniel Elisabeth, Christèle Huon, Elisabeth Carniel (87260), Ducos-Galand Magaly, Mohamed Zouine, Mazel, Didier, Biliana Lesic (45391), Elisabeth Carniel, Lesic, Biliana, Rosso, Marie-Laure, Mazel Didier, Prévost, Marie-Christine, Mohamed Zouine (178847), Zouine Mohamed, Lesic Biliana, Huon, Christèle, Carniel, Elisabeth, Rosso Marie-Laure   +31 more
core   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in Eu-v-abl transgenic mice

, 2002
There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains.
Gerondakis, S (15500621), Speed, TP (15496982), Daly, MJ (15500615), Fridlyand, J (15500618), Cook, WD (15500468), Harris, AW (15500624), Symons, RCA (15500612), Simon James Foote (14736730)   +7 more
core  

A comprehensive comparison of comparative RNA structure prediction approaches

, 2004
Gardner PP, Giegerich R. A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics. 2004;5(1): 140.Background: An increasing number of researchers have released novel RNA structure analysis and prediction ...
Giegerich, R., Gardner, Paul P., Gardner, P. P., Paul P Gardner, Robert Giegerich, Giegerich, Robert, Giegerich Robert, Gardner Paul P   +7 more
core   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Genome-wide scan for adult onset primary open angle glaucoma

, 2000
Adult onset primary open angle glaucoma is a leading cause of blindness throughout the world. The disease results in an apoptotic death of retinal ganglion cells that is usually associated with an elevation of intraocular pressure.
DelBono, E A, Wiggs, J L, Pericak-Vance, M, Hossain, A, Kern, J, Broomer, B, Allingham, R R, Haines, J L, Auguste, J, Graham, F L, Hauser, M   +10 more
core   +1 more source