Results 191 to 200 of about 170,056 (221)

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine From Xylose in Escherichia Coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

Endogenous Processes Underlying Clock-Like Mutational Signatures. [PDF]

Genes Chromosomes Cancer
Druck T, Aqeilan RI, Aldaz CM, Zanesi N, Huebner K.   +4 more
europepmc   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Mitochondrial Adaptations Underlying Tetraploidization in Human Cancer, Fungal, and Yeast Models. [PDF]

Biology (Basel)
Jemaà M, Bedoui A, Ammous N, Gargouri A, Guerfali M.   +4 more
europepmc   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

SLUR(M)-py: a SLURM powered Pythonic pipeline for parallel processing of 3D (Epi)genomic profiles. [PDF]

Epigenomics
Roth C, Venu V, Bacot S, Starkenburg SR, Steadman CR.   +4 more
europepmc   +1 more source

A comparison of spermatogenesis between flies and men-conserved processes of male gamete production. [PDF]

Hum Reprod Update
Houston BJ, Cauchi LM, Dunleavy JEM, Burke R, Hime GR, O'Bryan MK.   +5 more
europepmc   +1 more source

Chromosome-level haplotype-resolved genome assembly provides insights into the highly heterozygous genome of Italian ryegrass (Lolium multiflorum Lam.). [PDF]

Plant Genome
Chen Y, Kiesbauer J, Copetti D, Frei D, Frey JE, Grieder C, Kölliker R, Studer B.   +7 more
europepmc   +1 more source

Whole-Genome Resequencing Analysis Reveals Insights into Sex Determination and Gene Loci Associated with Sex Differences in <i>Procambarus clarkii</i>. [PDF]

Int J Mol Sci
Li J, Chen Y, Wang Y, Liu S.
europepmc   +1 more source

The regulatory mechanisms controlling meiotic cross-over patterning in plants. [PDF]

Biochem Soc Trans
Xu W, Lian Q, Li M, Copenhaver GP, Wang Y.   +4 more
europepmc   +1 more source