Results 181 to 190 of about 422,101 (237)

Landscape of rare-allele variants in cultivated and wild soybean genomes. [PDF]

Plant Genome
Liu Z, Shi X, Yang Q, Li Y, Yang C, Zhang M, An YC, Nguyen HT, Yan L, Song Q.   +9 more
europepmc   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

Chromosome-level genome assembly of the doctor fish (Garra rufa). [PDF]

Sci Data
Kon T, Kon-Nanjo K, Handayani KS, Zang L, Fahrurrozi F, Simakov O, Gultom VDN, Shimada Y.   +7 more
europepmc   +1 more source

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Near-complete Middle Eastern genomes refine autozygosity and enhance disease-causing and population-specific variant discovery. [PDF]

Nat Genet
Ghorbani M, Moosa S, Siddig Z, Farhad R, Naeem H, Harvey WT, Mastrorosa FK, Munson KM, Mohamad Razali R, Aliyev E, Diboun I, Abouelhassan R, Tauro M, Hassan S, Mathew R, Al Hashmi M, Mathew LS, Wang K, Salhab AR, Vempalli FR, El Khouly A, Qatar Genome Program Research Consortium, Alazwani I, Tomei S, Fakhro KA, Satti A, Benini R, Rhie A, Eichler EE, Mokrab Y.   +29 more
europepmc   +1 more source

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Chromosome architecture and low cohesion bias acrocentric chromosomes towards aneuploidy during mammalian meiosis. [PDF]

Nat Commun
Bellou E, Zielinska AP, Mönnich EU, Schweizer N, Politi AZ, Wellecke A, Sibold C, Tandler-Schneider A, Schuh M.   +8 more
europepmc   +1 more source

Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length

Advanced Science, EarlyView.
Different from mitosis, the female meiosis undergoes asymmetric division that produces haploid oocytes and polar body, which is essential for retaining maternal components to support subsequent fertilization and embryo development. However, the underlying mechanisms are still largely unknown.
Yu Li, Hanwen Zhang, Wenjun Zeng, Yilong Miao, Shaochen Sun, Yu Zhang, Bo Xiong   +6 more
wiley   +1 more source

Cytogenomic Characterization of Murine Cell Line Sarcoma 180 = S-180. [PDF]

Int J Mol Sci
Liehr T, Rincic M.
europepmc   +1 more source

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source