Results 181 to 190 of about 488,806 (311)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Genetic mapping and nuclear interactions of an incompatibility response in Agaricus bisporus. [PDF]

G3 (Bethesda)
Scholtmeijer K, Auxier B, Hendrickx P, Lavrijssen B, Debets AJM, Baars JJP, Aanen DK, van Peer AF.   +7 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

The chromosomes of reindeer (Rangifer tarandus)

Rangifer, 1986
Ulla Gripenberg, Mauri Nieminen
doaj   +1 more source

Satellite DNA sequence dictates pericentromere heterochromatin formation and function. [PDF]

Sci Adv
Lamelza P, Parrado M, Leara K, Balboula AZ, Keane TM, Lampson MA.   +5 more
europepmc   +1 more source

Auto‐Downregulation of the Florigen FT Production Prevents Precocious Flowering in Plants

Advanced Science, EarlyView.
This study shows that the leaf vein‐expressed FD complexes with the florigen FT to bind DNA motifs in FT promoter, which antagonizes CONSTANS‐mediated FT activation to feedback down‐regulate FT expression. This prevents an excessive induction of FT expression by inductive photoperiods, thereby precluding precocious transition to flowering in ...
Shu Tian, Xiao Luo, Bowen Cui, Yuehui He
wiley   +1 more source

High-resolution global recombination mapping in C. elegans reveals sexual dimorphisms shaped by meiotic chromosomal features and structures. [PDF]

PLoS Genet
Bush ZD, Conery JS, Wilson HR, Naftaly AFS, Dinwiddie D, Hillers KJ, Libuda DE.   +6 more
europepmc   +1 more source

CHROMOSOMES IN CANCER.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1996
No ...
openaire   +2 more sources

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Utility of Optical Genome Mapping in the Characterisation of the Global Genomic Architecture of Paediatric Central Nervous System Tumours: A Pilot Study. [PDF]

Neuropathol Appl Neurobiol
Alesi V, Genovese S, Russo S, Giovannoni I, Barresi S, Tancredi C, Pedace L, Arienzo F, Lombardo A, Bontempo P, Agolini E, Calacci C, Morgia A, Calvieri G, Puggioni C, Cardoni A, Cacchione A, Del Baldo G, Colafati GS, Carai A, Mastronuzzi A, Miele E, Abeni D, Locatelli F, Muda AO, Novelli A, Alaggio R, Rossi S.   +27 more
europepmc   +1 more source