Results 151 to 160 of about 4,397,402 (317)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Complementary and alternative medicine use and pain characteristics in older Vietnamese adults with chronic pain: A cross-sectional study. [PDF]

Belitung Nurs J
Trieu NTT, Hoai NTY, Thuy PT, Dung PTA, Ninh DT.   +4 more
europepmc   +1 more source

Toxicity of Sodium Molybdate and Sodium Dichromate to Daphnia magna Straus Evaluated in Acute, Chronic, and Acetylcholinesterase Inhibition Tests

, 2000
Teresa C. Diamantino, Lúcia Guilhermino, Elisabete Almeida, Amadeu M.V.M. Soares   +3 more
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

CHRONIC MENINGITIS

Medicine, 1976
J J, Ellner, J E, Bennett
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The State of Hepatitis B in Florida in 2025: Current Challenges and Health Disparities. [PDF]

J Viral Hepat
Nejat C.
europepmc   +1 more source

Chronic low back pain among French healthcare workers and prognostic factors of return to work (RTW): a non-randomized controlled trial [PDF]

, 2015
Baptiste Cougot, Audrey Petit, C. Paget, Claude Roedlich, Ghozlane Fleury‐Bahi, Marina Lang Fouquet, P. Menu, Christina M. DuBois, Christian Géraut, Yves Roquelaure, Dominique Tripodi   +10 more
openalex   +1 more source

CHRONIC AMOEBIASIS AND CHRONIC APPENDICITIS [PDF]

BMJ, 1935
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source