Results 61 to 70 of about 7,658,149 (357)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts [PDF]

, 2014
BACKGROUND: This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in five cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air ...
Adam, M, Al-Kanaani, Z, Beelen, R, Birk, M, Brunekreef, B, Buschka, A, Cai, Y, Carsin, A, Cirach, M, Clavel-Chapelon, F, de Hoogh, K, de Nazelle, A, Declercq, C, Ducret-Stich, RE, Forsberg, B, Gerbase, MW, Hansell, AL, Hardy, R, Heinrich, J, Hoek, G, Jacquemin, B, Jarvis, D, Kauffmann, F, Keidel, D, Krämer, U, Kuh, D, Künzli, N, Marcon, A, Nieuwenhuijsen, MJ, Probst-Hensch, N, Ragettli, MS, Ranzi, A, Rochat, T, Sanchez, M, Schikowski, T, Schindler, C, Sugiri, D, Sunyer, J, Temam, S, Tsai, M, Valeria Ferretti, V, Varraso, R, Vierkötter, A   +42 more
core   +1 more source

Cerebellar Morphometry and Cognition in the Context of Chronic Alcohol Consumption and Cigarette Smoking. [PDF]

, 2020
BackgroundCerebellar atrophy (especially involving the superior-anterior cerebellar vermis) is among the most salient and clinically significant effects of chronic hazardous alcohol consumption on brain structure.
Cootes T, Fregly AR, Harper CG, Sullivan EV, Victor M, Wang X   +5 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Cognitive Impairment and Psychopathology Are Related to Plasma Oxidative Stress in Long Term Hospitalized Patients With Chronic Schizophrenia

Frontiers in Psychiatry, 2022
BackgroundThe present study aimed to examine whether plasma oxidative stress is associated with cognitive impairment in long term hospitalized patients with chronic schizophrenia.MethodNinety-six chronic schizophrenia patients and 94 healthy unaffected ...
Man Yang, Jin Li, Haidong Yang, Linya Yan, Dongliang Liu, Lin Zhu, Xiaobin Zhang   +6 more
doaj   +1 more source

ROLE OF ANATOMICAL OBSTRUCTION IN THE PATHOGENESIS OF CHRONIC SINUSITIS [PDF]

, 2012
Sinusitis is a commonly diagnosed condition in the general population.This article is a study to asses the role of anatomical obstruction in the pathogenesis of chronic sinusitis,based on symptomatology and radiological findings of the patients.The ...
Basith, Yahia Abdul, Thiagarajan, Balasubramanian   +1 more
core   +2 more sources

CHRONIC PANCREATITIS [PDF]

BMJ, 1919
n ...
openaire   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes

BMC Immunology, 2011
Background Prolonged alcohol consumption is a significant co-factor in the progression of chronic viral infections including hepatitis C and HIV, which are both single-stranded RNA viruses.
Kodys Karen, Bala Shashi, Pang Maoyin, Catalano Donna, Szabo Gyongyi   +4 more
doaj   +1 more source

Chronic urticaria

Indian Journal of Dermatology, 2011
Chronic urticaria (CU) is a disturbing allergic condition of the skin. Although frequently benign, it may sometimes be a red flag sign of a serious internal disease. A multitude of etiologies have been implicated in the causation of CU, including physical, infective, vasculitic, psychological and idiopathic.
Sandeep Sachdeva, Vibhanshu Gupta, Syed Suhail Amin, Mohd Tahseen   +3 more
openaire   +3 more sources