Results 71 to 80 of about 7,658,149 (357)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

The influence of Helicobacter pylori infection on the occurrence of gastroesophageal reflux in patients with renal insufficiency [PDF]

Vojnosanitetski Pregled, 2007
Introduction/Aim. Gastric acid is a key factor in the pathophysiology of gastroesophageal reflux disease. A plausible mechanism by which the Helicobacter pylori infection might protect against reflux disease is by its propensity to produce atrophic ...
Stolić Radojica, Jovanović Aleksandar, Perić Vladan, Trajković Goran, Živić Živa, Stolić Dragica, Lazarević Tatjana, Sovtić Saša   +7 more
doaj   +1 more source

Evaluation of the Conrad N. Hilton Foundation Chronic Homelessness Initiative: 2015 [PDF]

, 2015
Under a September 2011 contract with the Conrad N. Hilton Foundation, Abt Associates has been conducting an evaluation of the Hilton Foundation's Chronic Homelessness Initiative, with the goal of answering the overarching question: Is the Chronic ...

core  

Chronic pancreatitis [PDF]

The Lancet
Chronic pancreatitis is a progressive fibroinflammatory disease primarily caused by a complex interplay of environmental and genetic risk factors. It might result in pancreatic exocrine and endocrine insufficiency, chronic pain, reduced quality of life, and increased mortality.
Thierens, N.D.E., Verdonk, R.C., Löhr, J.M., Santvoort, H.C. van, Bouwense, S.A.W., Hooft, Jeanin E. van   +5 more
openaire   +4 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Is traumatic and non-traumatic neck pain associated with brain alterations? : a systematic review [PDF]

, 2017
Background: Chronic neck pain affects 50% - 85% of people who have experienced an acute episode. This transition and the persistence of chronic complaints are believed to be mediated by brain alterations among different central mechanisms.
Caeyenberghs, Karen, Cagnie, Barbara, Coppieters, Iris, Danneels, Lieven, De Pauw, Robby, Meeus, Mira   +5 more
core  

Acute and Chronic Effects of Smoking on Inflammation Markers in Exhaled Breath Condensate in Current Smokers [PDF]

, 2010
Background: Long-term cigarette smoking is associated with pulmonary inflammation, but the acute effects of smoking have been less well studied. Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that might be indicative of ...
Bals, Robert, Herr, Christian, Jörres, Rudolf A., Koczulla, A. Rembert, Noeske, Sarah, Römmelt, Horst, Vogelmeier, Claus   +6 more
core   +1 more source

Health-related quality of life as measured with EQ-5D among populations with and without specific chronic conditions: A population-based survey in Shaanxi province, China [PDF]

, 2013
© 2013 Tan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
A Alwan, A Yeung, AL Supina, AS Pickard, CLK Lam, David W. Dowdy, E Pappa, EI Lubetkin, F Gao, F Tian, GH Yang, GLK Hsu, H Picavet, H Sakamaki, Haibo Tu, JB Williamson, JE Ware Jr, JW Hou, JW Shaw, LD Wang, Lingxia Guo, M Javanbakht, MJ Calvert, MTD Dyer, R Brooks, R Rabin, R Tajima, S Sun, Siming Liu, SS Shi, Wenjun Cao, WJ Furlong, YF Yu, Ying Liang, Yongyong Xu, YT Zhang, Zhijun Tan   +36 more
core   +7 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Optimization of adefovir therapy in chronic hepatitis B according to baseline predictors and on-treatment HBV DNA: a 5-Year prospective study

Virology Journal, 2011
Background Adefovir Dipivoxil (ADV) is an important agent to suppress hepatitis B virus (HBV) replication with suboptimal effect on virological and serological response.
Zhang Jing, Shen Fei, Geng Da, Lu Hui, Lu Bing, Ma Li   +5 more
doaj   +1 more source