Results 51 to 60 of about 254,563 (216)

Chronic Abdominal Discomfort Syndrome (CADS): Defining and Discussing a Novel Diagnosis

Journal of Pain Research
Mayank Gupta,1,* Anand S Patil,2,* Ahish Chitneni,3 Michael E Schatman,4 Hemant Kalia,5 Timothy R Deer,6 Dawood Sayed,7 Amol Soin,8 Ganesan Baranidharan,9 Peter Staats,10 Leonardo Kapural,11 Phani Ashok Attaluri,12 Paul Verrills,13 Sudhir Diwan ...
Gupta M, Patil AS, Chitneni A, Schatman ME, Kalia H, Deer TR, Sayed D, Soin A, Baranidharan G, Staats P, Kapural L, Attaluri PA, Verrills P, Diwan S, Levin D, Halder N, Abd-Elsayed AA   +16 more
doaj  

Can Machine Learning Reduce Unnecessary Surgeries? A Retrospective Analysis Using Threshold Optimization to Prevent Negative Appendectomies in Adults

Annals of Gastroenterological Surgery, EarlyView.
Threshold‐optimized machine learning models using routine clinical and laboratory data in 623 adults undergoing appendectomy. Logistic regression (AUC = 0.765) and random forest (AUC = 0.785) were the best‐performing models for appendicitis detection and complicated appendicitis prediction, respectively.
Ivan Males, Marko Kumric, Zvonimir Boban, Josip Vrdoljak, Dario Pecenkovic, Matej Ivanda, Marko Grahovac, Zenon Pogorelic, Josko Bozic   +8 more
wiley   +1 more source

Single‐Incision Laparoscopy‐First Strategy in Crohn's Disease: Risk Factors for Conversion and Surgical Outcomes

Annals of Gastroenterological Surgery, EarlyView.
In this retrospective study of 289 patients with Crohn's disease undergoing a single‐incision laparoscopy‐first (SILS‐first) strategy, conversion to open surgery was required in only 11.8% of cases. Fistula formation, colon resection, and smoking history were identified as independent risk factors for conversion, while postoperative complications and ...
Yuki Horio, Motoi Uchino, Yusuke Tomoo, Kentaro Nagano, Kurando Kusunoki, Ryuichi Kuwahara, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Hiroki Ikeuchi   +9 more
wiley   +1 more source

Chronic Abdominal Discomfort Syndrome (CADS): A Narrative Review of Treatment Strategies

Journal of Pain Research
Mayank Gupta,1,* Anand S Patil,2,* Peter Staats,3 Michael E Schatman,4 Hemant Kalia,5 Dawood Sayed,6 Amol Soin,7 Ganesan Baranidharan,8 Leonardo Kapural,9 Ahish Chitneni,10 Paul Verrills,11 Sudhir Diwan,12 Alaa A Abd-Elsayed,13 Timothy R ...
Gupta M, Patil AS, Staats P, Schatman ME, Kalia H, Sayed D, Soin A, Baranidharan G, Kapural L, Chitneni A, Verrills P, Diwan S, Abd-Elsayed AA, Deer TR   +13 more
doaj  

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Evaluation of Endoscopic and Pathological Findings of the Upper Gastrointestinal Tract in Children with Asymptomatic Chronic Abdominal Pain Aged 3 to 12 Years [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Chronic abdominal pain or recurrent abdominal pain is defined as abdominal pain that occurs in at least three episodes, lasting for a minimum of three consecutive months, and is severe enough to adversely affect the child's normal
Azra Peirovi, Mohammad eshagh Rozeh, Seyed Ali naghi Kazemi, Reza Mahdian-Joybari, Farzaneh Ahmadi   +4 more
doaj  

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Chronic epigastric pain associated with gastric anisakidosis

IDCases, 2019
Anisakidosis is an acute and, less commonly, chronic gastrointestinal tract disease caused by the ingestion of nematode larvae contained within raw or undercooked seafood.
Christine Bookhout, Kevin Greene
doaj   +1 more source

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source