Results 231 to 240 of about 3,488,730 (309)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

COCCOS: a blueprint transition program for young people with chronic conditions using experience-based co-design. [PDF]

BMC Public Health
Janssens N, Van Wilder L, Vanden Wyngaert K, Van Hecke A, Van Hoorenbeeck K, Dupont E, Moerkens M, De Smedt D, Goossens E.   +8 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Trends in Hospital Resource Use for Children With Complex Chronic Conditions.

JAMA Netw Open
Bayer ND, Hall M, Osipovich M, Morrison JM, Pulcini CD, Leary JC, Thomson JE, Simon TD, Kuo DZ, Colvin JD, Cohen E, Berry JG.   +11 more
europepmc   +1 more source

Traditional, complementary and integrative health within universal systems: a transdisciplinary integrative approach to chronic conditions in the Brazilian SUS. [PDF]

Front Public Health
Cohrs FM, Bignardi FAC.
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Implementing exergames into healthcare for chronic conditions - insights from stakeholders: a qualitative study. [PDF]

Health Res Policy Syst
Antoniadou M, Zelko A, Strömberg A, Jaarsma T, Klompstra L.   +4 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Chronic Conditions and Food Insecurity in US Children.

JAMA Netw Open
Hill NE, Palakshappa D, Chua KP.
europepmc   +1 more source

Editorial: The role of nutritional supplements and oral complementary or alternative medicine supplements for the management of chronic conditions in children. [PDF]

Front Pediatr
Vernon-Roberts A, Day AS.
europepmc   +1 more source