Results 121 to 130 of about 92,292 (242)

When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions

Movement Disorders, EarlyView.
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel, Robert S. Eisinger, Joyce M. Lee, Sarah Hamimi, Hope Kim, Susanna D. Howard, Casey H. Halpern   +6 more
wiley   +1 more source

Unlocking the colon clock: Bridging the gap in colonic transit time studies for optimal management of chronic constipation. [PDF]

World J Gastrointest Pharmacol Ther
Kalra S, Goyal MK, Goyal K, Singh R, Vuthaluru AR, Goyal O.   +5 more
europepmc   +1 more source

Washed Microbiota Transplantation Using Ileocolic Transendoscopic Enteral Tubing Versus Basic Treatments for Intestinal Inflammatory Obstruction in Crohn's Disease: A Multicenter Concurrent Controlled Trial

Microbiota Medicine Research, EarlyView.
Washed microbiota transplantation using ileocolic transendoscopic enteral tubing was identified as a viable, effective and safe bridge treatment for intestinal inflammatory obstruction in Crohn's disease, demonstrating significantly higher 28‐day improvement rates compared to basic treatment.
You Yu, Xinlu Jin, Zhaoyang Zhao, Weihong Wang, Fan Xu, Chengran Wang, Sibusiso Luthuli, Xiaoshuang Xu, Quan Wen, Bota Cui, Honggang Wang, Faming Zhang   +11 more
wiley   +1 more source

Early Therapeutic Response Predicts Outcome in Chronic Constipation: A Multicenter Prospective Observational Study. [PDF]

Gastroenterology Res
Oshima T, Futagami S, Tanaka Y, Hojo M, Isshi K, Kakimoto K, Uchiyama Y, Iida H, Oshio A, Nakada K.   +9 more
europepmc   +1 more source

β3‐Adrenoceptor Agonists for Neurogenic Lower Urinary Tract Dysfunction: Evidence and Clinical Rationale for First‐Line Therapy

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims To summarize current evidence on β3‐adrenoceptor agonists for managing neurogenic lower urinary tract dysfunction (NLUTD), focusing on their efficacy, safety, and clinical role in optimizing bladder storage and protecting upper tracts. Methods Evidence from randomized controlled trials, meta‐analyses, and observational studies in spinal ...
Sharon E. Fishberg, Rano Matta
wiley   +1 more source

The Actual Condition of Chronic Constipation in Real-World Clinical Settings and Its Impact on Various Aspects of Daily Life. [PDF]

Dig Dis
Hojo M, Oshima T, Futagami S, Isshi K, Ihara E, Yamaguchi Y, Manabe N, Chibai M, Kamada K, Oshio A, Nakada K.   +10 more
europepmc   +1 more source

Addressing the distressing: Pancreatic enzyme replacement therapy mitigates abdominal symptoms and weight loss during chemotherapy for advanced pancreatic cancer: A prospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Pancreatic enzyme insufficiency (PEI) contributes to symptom burden and malnutrition in advanced pancreatic cancer (aPC). We aimed to evaluate the impact of pancreatic enzyme replacement therapy (PERT) on symptom burden and weight during chemotherapy.
Pamela N. Klassen, Christina A. Kim, Jessica Kasnik, Michael B. Sawyer, Sunita Ghosh, Vickie Baracos, Vera C. Mazurak   +6 more
wiley   +1 more source

Review of nutrition management of pediatric intestinal pseudo‐obstruction

Nutrition in Clinical Practice, EarlyView.
Abstract Chronic intestinal pseudo‐obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction.
Senthilkumar Sankararaman, Raisa Rani James, Bushra El‐Amaireh, Andrea Adler, Kadakkal Radhakrishnan, Sujithra Velayuthan   +5 more
wiley   +1 more source

Short-Term Efficacy and Safety of Elobixibat for Chronic Constipation Assessed by Rectal Ultrasonography: A Retrospective Observational Study. [PDF]

Diagnostics (Basel)
Tsuda M, Onodera T, Konishi K, Maiya N, Matsumoto M, Kubo K, Kudo S, Hosoi Y, Kato M.   +8 more
europepmc   +1 more source

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection, EarlyView.
Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
wiley   +1 more source