Results 131 to 140 of about 84,272 (327)
Clinical Pharmacology in Drug Development, EarlyView.Abstract This study (NCT04537715) investigated itraconazole (strong cytochrome P450 [CYP] 3A inhibitor) and rifampin (strong CYP3A inducer) on tazemetostat pharmacokinetics. In Part 1, patients received tazemetostat 400 mg orally on Days 1, 15, and 36, and 400 mg twice daily on Days 3‐14 and Days 21‐35.
Yingxue Chen +6 more
wiley +1 more source
Association between ideal cardiovascular health and bowel conditions among US adults
Frontiers in NutritionObjectiveThe aim of this study is to explore the relationship between ideal cardiovascular health (CVH), as assessed using the Life’s Essential 8 (LE8), and bowel conditions.MethodsThis cross-sectional study selected 11,108 participants aged ≥20 years ...
Yiwen Wang, Zhigang Wang
doaj +1 more source
Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study [PDF]
, 2015 Context Patients’ preference for morphine therapy has received little attention in the setting of chronic refractory breathlessness. However, this is one important factor in considering longer term therapy.
Abernethy, Amy P. +6 more
core +1 more source
Temperate and chronic virus competition leads to low lysogen frequency [PDF]
arXiv, 2019 The canonical bacteriophage is obligately lytic: the virus infects a bacterium and hijacks cell functions to produce large numbers of new viruses which burst from the cell. These viruses are well-studied, but there exist a wide range of coexisting virus lifestyles that are less understood.
arxiv
Epilepsia Open, EarlyView.Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza +4 more
wiley +1 more source
Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson\u2019s disease [PDF]
, 2018 Background: Pain is a common and undertreated non-motor symptom in patients with Parkinson\u2019s disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions.
Freo, Ulderico +2 more
core
Latest Progresses in Developing Wearable Monitoring and Therapy Systems for Managing Chronic Diseases [PDF]
arXiv, 2018 Chronic disease is a long-lasting condition that can be controlled but not cured. Owing to the portability and continuous action, wearable devices are regarded as promising ways for management and rehabilitation of patients with chronic diseases. Although the monitoring functions of mobile health care are in full swing, the research direction along ...
arxiv
The Prevalence of Excessive Exercise in Eating Disorders: A Systematic Review and Meta‐Analysis
European Eating Disorders Review, EarlyView.ABSTRACT Objective Individuals with eating disorders (EDs) often present with maladaptive behaviours such as excessive exercise (EE). The consequences of EE include physical injuries, increased risk of anxiety and depression, and impaired social functioning. No systematic reviews have been conducted on the prevalence of EE in EDs.
Connor Campbell +8 more
wiley +1 more source
A Review of the Role of Melatonin in Irritable Bowel Syndrome [PDF]
, 2014 Irritable bowel syndrome (IBS) is a troubling disease experienced worldwide. The presentation of symptoms varies from patient to patient, and current prescription treatments can be inadequate in resolving symptoms.
Brinn, Nicole R., Gandhi, Mona A.
core +1 more source