Results 131 to 140 of about 2,827,577 (391)

Deprescribing drugs with anticholinergic effects in older patients with increased risk of dementia in the multicomponent intervention study AgeWell.de

British Journal of Clinical Pharmacology, EarlyView.
Aim Drugs with anticholinergic effects are often considered as potentially inappropriate medications, especially for older patients, and deprescribing such drugs may improve cognitive function. The aim was to investigate the effectiveness of counselling on drug risks as part of a multimodal intervention to prevent cognitive decline. Methods The AgeWell.
Laura K. Lepenies, Hanna M. Seidling, Alexander Pabst, Melanie Luppa, Juliane Döhring, Martin Williamson, Thomas Frese, Jochen Gensichen, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans‐Helmut König, Jochen René Thyrian, Birgitt Wiese, Steffi G. Riedel‐Heller, David Czock   +14 more
wiley   +1 more source

Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

Scientific Reports, 2017
Chronic constipation is a prevalent functional gastrointestinal disorder accompanied with intestinal dysbiosis. However, causal relationship between dysbiosis and constipation remains poorly understood.
H. Cao, Xiang Liu, Yingying An, Guoqiong Zhou, Yanrong Liu, Mengque Xu, Wenxiao Dong, Sinan Wang, Fang Yan, Kui Jiang, Bangmao Wang   +10 more
semanticscholar   +1 more source

Optimizing Peripheral Nerve Block Placement in Hip Surgery: A Cadaveric Study Mapping the Posterior Cutaneous Innervation

Clinical Anatomy, EarlyView.
ABSTRACT Optimizing analgesia after hip surgery enables more rapid recovery. However, peripheral nerve blocks (PNBs) often fail to provide adequate pain relief in the posterolateral hip as they typically target the lateral cutaneous nerve of the thigh (LCNT).
Ziki Gurney, Kenneth Saw Kai Wei, Leia Boote, Daniel Gareth Stolady, Benjamin Fox, Alan R. Norrish   +5 more
wiley   +1 more source

Relationship Between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients With Chronic Constipation.

Gastroenterology, 2016
BACKGROUND & AIMS In fecal samples from patients with chronic constipation, the microbiota differs from that of healthy subjects. However, the profiles of fecal microbiota only partially replicate those of the mucosal microbiota.
G. Parthasarathy, Jun Chen, Xianfeng Chen, N. Chia, H. O'Connor, Patricia G. Wolf, H. Gaskins, A. Bharucha   +7 more
semanticscholar   +1 more source

Symptom Onset in Classic Rett Syndrome: Analysis of Initial Clinical Severity Scale Entries

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective We aim to assess the clinical features of Rett syndrome (RTT) at registration into the National Institutes of Health–sponsored natural history study (NHS) using the Clinical Severity Scale (CSS). Introduction The CSS was established in 2000 to assess characteristics of individuals with RTT and related disorders.
Alan K. Percy, Jeffrey L. Neul, Amitha Ananth, Timothy A. Benke, Eric D. Marsh   +4 more
wiley   +1 more source

Roles of Chinese Medicine and Gut Microbiota in Chronic Constipation

Evidence-Based Complementary and Alternative Medicine, 2019
Chronic constipation is a common gastrointestinal dysfunction, but its aetiology and pathogenesis are still unclear. Interestingly, the compositions of the gut microbiota in constipation patients and healthy controls are different.
Zhenyuan Xu, Tian-hao Liu, Qingli Zhou, Jing Chen, Jia-li Yuan, Zhongshan Yang   +5 more
semanticscholar   +1 more source

Safety and Efficacy of the NMDA‐2b‐Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder

Clinical Pharmacology &Therapeutics, EarlyView.
Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre, Gerard Sanacora, David P. Walling, Elan A. Cohen, Shishuka Malhotra, Holger Rosenbrock, Manuela Schmitz, Andreas Scholz, Sigurd D. Süssmuth, Franco De Crescenzo   +9 more
wiley   +1 more source

Current developments in pharmacological therapeutics for chronic constipation

Acta Pharmaceutica Sinica B, 2015
Chronic constipation is a common gastrointestinal disease severely affecting the patient׳s quality of life. The traditional treatment of constipation is the use of laxatives.
Chunhuan Jiang, Qinglong Xu, Xiaoan Wen, Hongbin Sun   +3 more
doaj   +1 more source

Federated Tensor Factorization for Computational Phenotyping

, 2017
Tensor factorization models offer an effective approach to convert massive electronic health records into meaningful clinical concepts (phenotypes) for data analysis. These models need a large amount of diverse samples to avoid population bias.
Jiang, Xiaoqian, Kim, Yejin, Sun, Jimeng, Yu, Hwanjo   +3 more
core   +1 more source

Laxatives do not improve symptoms of opioid-induced constipation: results of a patient survey [PDF]

, 2017
Introduction: Laxatives are commonly used to treat opioid-induced constipation, the commonest and most bothersome complication of opioids. However, laxatives have a non-specific action and do not target underlying mechanisms of opioid-induced ...
Emmanuel, Anton, Johnson, Martin, McSkimming, Paula   +2 more
core   +1 more source