Results 161 to 170 of about 165,253 (350)

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Calcium butyrate efficacy in pediatric irritable bowel syndrome: Randomized placebo‐controlled multiomics‐based clinical trial

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, and treatment involves nonpharmacological and pharmacological therapies, even if there is no optimal therapy. This randomized, placebo‐controlled, double‐blind trial aimed to evaluate the efficacy of calcium butyrate supplementation in ...
Fernanda Cristofori, Francesco Maria Calabrese, Ilaria Iacobellis, Monica Santamaria, Giuseppe Celano, Ilario Ferrocino, Emanuela Di Sabato, Rocco Pergola, Vanessa N. Dargenio, Leonardo Paulucci, Maria De Angelis, Ruggiero Francavilla   +11 more
wiley   +1 more source

Psyllium is superior to docusate sodium for treatment of chronic constipation [PDF]

, 1998
Mcrorie, Daggy, Morel, Diersing, Miner, Robinson   +5 more
openalex   +1 more source

Genital Crohn's disease in pediatrics and genetic associations

JPGN Reports, EarlyView.
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote ...
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak   +5 more
wiley   +1 more source

INFORMATIVE ENERGY EXCHANGE OF PERIPHERAL LYMPHOCYTE BLOOD MITOCHONDRIA IN CHILDREN WITH CHRONIC CONSTIPATION

Вопросы современной педиатрии, 2007
The article discusses the study of cell metabolism condition in chronic constipation children based on the activities of the two mitochondrion enzymes, succinate dehydrogenate and glycerophosphate dehydrogenase detected in cytochemical analysis of blood ...
G.F. Semenova, E.V. Komarova, A.S. Potapov, A.V. Petrova, V.M. Shishchenko, S.V. Petrichuk   +5 more
doaj   +2 more sources

Hematochezia: An abnormal presenting symptom of an extensive vascular malformation in a 6‐year‐old boy

JPGN Reports, EarlyView.
Abstract Gastrointestinal (GI) bleeding can be a common symptom in the pediatric population. Vascular malformations, which cause symptoms based on their location and effect on surrounding structures, are an uncommon cause of GI bleeding. We present the case of a 6‐year‐old male with a 1‐year history of hematochezia, constipation, and microcytic anemia.
Kathleen Ordas, Joy Brusenback, Sahana Ummadi, Shannon Tocchio, Razan Alkhouri, Soha Shah   +5 more
wiley   +1 more source

Diagnostic dilemmas and results of treatment for chronic constipation. [PDF]

, 1996
C.W. Keuzenkamp-Jansen, C. J. Fijnvandraat, C. M. F. Kneepkens, A. C. Douwes   +3 more
openalex   +1 more source

Anorectal gastric heterotopia as a rare cause of constipation: Case report and review of pediatric literature

JPGN Reports, EarlyView.
Abstract Gastric heterotropia (GHT) may present from the oropharynx to the anus and is commonly associated with Meckel's diverticula. Here, we describe a rare case of anorectal GHT localized to the distal anal canal. A 14‐month‐old male patient presented for evaluation of rectal bleeding, severe constipation, and abdominal distention with poor response
Kathryn M. Stephenson, Raj P. Kapur, Jeffrey R. Avansino, Lusine Ambartsumyan   +3 more
wiley   +1 more source

Frequency of Digital Rectal Examination in Children With Chronic Constipation [PDF]

, 1999
David Gold, Jeremiah Levine, Toba Weinstein, Bradley H. Kessler, Michael J. Pettei   +4 more
openalex   +1 more source

The Interplay between Hormones and Irritable Bowel Disease [PDF]

, 2013
Thesis (M.A.)--Boston UniversityThis thesis examines the underlying mechanisms causing the severe and often debilitating symptoms associated with both Irritable Bowel Syndrome and Inflammatory Bowel Disease.
Linson, Elyse A.
core   +1 more source