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Chronic constipation in adults
BMJ, 2009#### Summary points Chronic constipation in adults is a common and often debilitating problem that may present to almost any medical practitioner as it can have many causes. The most recent Rome criteria provide a useful research and clinical tool for defining chronic, functional constipation (box 1).1 For the problem to be described as chronic, the ...
Mark Mercer-Jones +2 more
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Electrorectography in chronic constipation
World Journal of Surgery, 1995AbstractThe rectal electrical activity recorded by electrorectogram (ERG) was studied in 22 chronically constipated subjects and 16 healthy colunteers. The latter had a mean (±SD) age of 42.6±8.5 years; 10 were men and 6 women. Of the 22 constipated patients, 14 had inertia‐type age 38.4±12.2 years.
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Chronic Constipation in the Elderly
Gastroenterology Clinics of North America, 2009Chronic constipation is a common problem in the elderly, with a variety of causes, including pelvic floor dysfunction, medication effects, and numerous age-specific conditions. A stepwise diagnostic and therapeutic approach to patients with chronic constipation based on historical and physical examination features is recommended.
Eric G. Tangalos, Ernest P. Bouras
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Rectal sensitivity in chronic constipation
Digestive Diseases and Sciences, 1989Rectal sensitivity is often reduced in patients affected by chronic constipation, but it is not known whether this alteration differs according to the severity and the site(s) of the slowing of gastrointestinal transit. Moreover, it is not known whether alteration precedes or follows bowel complaints. In this study, perception of intrarectal distension
A. De Medici +4 more
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Velusetrag for the treatment of chronic constipation
Expert Opinion on Investigational Drugs, 2016Chronic constipation is a frequent complaint in daily clinical practice. Notwithstanding the availability of numerous drugs, its treatment it is still unsatisfactory. However, new emerging treatments are in the pipeline and some drugs seem to be promising; among these velusetrag, a selective 5-HT4 receptors agonist.An in depth Medline literature search
BASSOTTI, GABRIO +2 more
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Linaclotide for the treatment of chronic constipation
Expert Opinion on Pharmacotherapy, 2018Chronic constipation (CC) is a common gastrointestinal disorder with limited treatment options. Linaclotide is a potent peptide agonist of the guanylate cyclase-C receptor. This action activates intracellular conversion of guanosine 5-triphosphate to cyclic guanosine monophosphate resulting in the stimulation of intestinal fluid secretion.
Bassotti G., Usai-Satta P., Bellini M.
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