Results 31 to 40 of about 1,908,468 (288)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Glutamine Supplementation Effects on Reducing Inflammation in The Ileum of Acute and Chronic Diarrhea Rats Induced by Enteropathogenic Escherichia coli

Indonesian Biomedical Journal, 2020
BACKGROUND: Glutamine, a non-essential amino acid, is the main fuel in the gastrointestinal mucosa. It is thought to protect the intestinal mucosa against local or systemic injury from diarrhea.
Deddy Satriya Putra, Fadil Oenzil, Eryati Darwin, Hafni Bachtiar, Tofrizal Tofrizal   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Chronic diarrhea associated with persistent norovirus excretion in patients with chronic lymphocytic leukemia: report of two cases

BMC Infectious Diseases, 2011
Background Chronic diarrhea in patients treated with immunosuppressive agents or suffering from immunosuppressive disease can represent a diagnostic and therapeutic challenge to the clinician. Norovirus infection, a major cause of acute epidemic diarrhea,
Steingart Richard, Makari-Judson Grace, Capizzi Todd, Mertens Wilson C   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Association of B vitamins with chronic constipation and diarrhea: a cross-sectional study based on data from NHANES

陆军军医大学学报
Objective To investigate the relationship between daily intake of B vitamins (vitamins B1, B2, B6 and niacin) and chronic constipation and chronic diarrhea.
DING Pei, WANG Lin, WANG Lin
doaj   +1 more source

Cryptosporidiosis in patients with diarrhea and chronic liver diseases

Journal of Infection in Developing Countries, 2014
Introduction: The aim of this study was to evaluate the epidemiology and clinical significance of Cryptosporidium in patients with diarrhea and chronic liver diseases. Methodology: The study included 150 patients with chronic liver diseases and diarrhea,
Nasser Mousa, Ahmed Abdel-Razik, Hala El-Nahas, Atef El-Shazly, Mohammad Abdelaziz, Marwa Nabih, Magdy Hamed, Mohammad Eissa, Narmin Effat, Walled Eldars   +9 more
doaj   +1 more source

Thymoma with chronic diarrhea

, 2007
Thymoma associated with hypogammaglobulinemia and profound susceptibility to recurrent and serious infections was first reported by Good in 1954, after whom it was named as Good's syndrome.
Kaynak, Kamil, CETIN, Sibel Erdamar, YANMAZ, Teoman, Ozguroglu, Mustafa, Akman, Canan, TURNA, Hande, Celik, AYKUT, Oz, Buge, Yildiz, Ozcan   +8 more
core   +1 more source

Pancreatic Exocrine Insufficiency in Chronic Diarrhea [PDF]

, 2005
Background: One of the causes of chronic diarrhea is pancreatic exocrine insufficiency. Chronic diarrhea cases are commonly encountered in Indonesia. Materials & methods: All patients with chronic diarrhea at hospitals in Jakarta were included in ...
Simadibrata, M. (Marcellus), Simadibrata, Marcellus, Hardjodisastro, D. (Daldiyono), Rani, Abdul Aziz, Rani, A. A. (Abdul), Hardjodisastro, Daldiyono   +5 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source