Results 41 to 50 of about 4,214,463 (259)

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Chronic cough due to occupational factors [PDF]

open access: yes, 2006
Within the large variety of subtypes of chronic cough, either defined by their clinical or pathogenetic causes, occupational chronic cough may be regarded as one of the most preventable forms of the disease.
Fischer, Axel   +3 more
core  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

Assessing chronic disease management in European health systems. Country reports [PDF]

open access: yes, 2015
Many countries are exploring innovative approaches to redesign delivery systems to provide appropriate support to people with long-standing health problems.
Knai, C, Nolte, E
core  

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

open access: yesMolecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang   +8 more
wiley   +1 more source

Chronic Disease and the Internet [PDF]

open access: yes, 2010
Compares survey data on access to and use of the Internet and social media by chronically ill and healthy adults, sources and topics of health information, and impact of online information.
Kristen Purcell, Susannah Fox
core  

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

2013 Barnwell County Obesity Fact Sheet [PDF]

open access: yes, 2013
This fact sheet provides information on nutrition, physical activity, and obesity for Barnwell ...
Department of Health and Environmental Control, Division of Chronic Disease Epidemiology
core  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

2013 Laurens County Obesity Fact Sheet [PDF]

open access: yes, 2013
This fact sheet provides information on nutrition, physical activity, and obesity for Laurens ...
Department of Health and Environmental Control, Division of Chronic Disease Epidemiology
core  

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