Results 121 to 130 of about 5,896,146 (297)
Rheumatoid Arthritis Therapy Based on B Cells
Drug Design, Development and TherapyYongqi Liang,1,* Menglei Zha,1,* Qifeng Liu,1 Zhifei Lai,1 Lei Li,1 Yiming Shao,2 Jianbo Sun1 1Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan ...
Liang Y +6 more
doaj
Development of Australian chronic disease targets and indicators [PDF]
, 2015 Analyses available baseline information for chronic diseases in Australia, as a starting point for chronic disease target and indicator consideration. Introduction The Australian Health Policy Collaboration (AHPC) is facilitating development of a set ...
Penny Tolhurst, Tolhurst, Penelope
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
CellsIn various neurodegenerative conditions, inflammation plays a significant role in disrupting the blood–brain barrier (BBB), contributing to disease progression.
Nuria Seoane +6 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Preventable chronic diseases in Aboriginal populations [PDF]
, 2009 The purpose of this paper is to provide background information about chronic diseases in the Aboriginal population in the NT and to stimulate input and comment to assist in the revision of the Preventable Chronic diseases Strategy (PCDS) and ...
core
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Journal of Translational MedicineBackground Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible interstitial lung disease with limited effective treatment options.
Caihong Luo +10 more
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