Results 131 to 140 of about 616,611 (358)
Advanced Science, EarlyView.Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma +15 more
wiley +1 more source
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source
The Public Health Impact of Antiviral Therapy for Chronic Hepatitis B [PDF]
, 2011 __Abstract__ Of the approximately 2 billion people who have been infected worldwide with the hepatitis B virus (HBV), more than 350 million are chronic carriers. HBV infection accounts for 600,000-1,200,000 deaths each year.
Toy, M. (Mehlika)
core +1 more source
Chronic hepatitis C genotype 6 responds better to pegylated interferon and ribavirin combination therapy than genotype 1 [PDF]
, 2009 Owen T‐Y Tsang +14 more
openalex +1 more source
The Professional Medical Journal, 2014 Objective: To determine the correlation between HCV genotypes and serum ALTlevels in various patients of chronic hepatitis induced by hepatitis C virus, in our setup. Design: Aprospective study carried out from August 2006 to December 2009. Setting: Research MedicalCenter LUMHS Jamshoro, Pathology Department Peoples University of Medical & ...
Anwar Ali Akhund +3 more
openaire +2 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Hepatology, EarlyView., 2022 Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai +29 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2011 The five known causes of acute hepatitis are the hepatitis A (HAV), B (HBV), C (HCV), D (HDV), and E (HEV) viruses. Hepatitis A and E are forms of infectious hepatitis which spread largely by the fecal-oral route, occur in outbreaks a well as ...
Hamid kalantari
doaj
Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation
Advanced Science, EarlyView.Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang +3 more
wiley +1 more source