Results 71 to 80 of about 616,613 (359)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Theexpert consensus for the diagnosis and treatment of chronic kidney disease with hepatitis C infection

Linchuang shenzangbing zazhi, 2019
慢性肾脏病（chronic kidney disease,CKD）是我国重要的公共健康问题,流行率约10.8%,据此推算,我国成人CKD患者约1.2亿[1]。根据肾小球滤过率（estimated glomerular filtration rate,eGFR）,CKD可分为1～5期[2]。CKD患者免疫功能低下,易受细菌、病毒及其他病原体感染,而血液透析患者更是丙型肝炎病毒（hepatitis C virus,HCV）感染的高危人群 ...
The committee of expert consensus for the diagnosis and treatment of chronic kidney disease with hepatitis Cinfection
doaj  

A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants

Virus Research
The detection of hepatitis B surface antigen (HBsAg) is fundamental for the diagnosis of chronic hepatitis B (CHB). However, current diagnostic assays that rely on antibodies targeting the conformational “a” determinant of HBsAg are frequently ...
Yansong Chen, Xinyu Zhang, Asha Ashuo, Zhong Fang, Wuhui Song, Jiangxia Liu, Jieliang Chen, Yaming Li, Zhenghong Yuan   +8 more
doaj   +1 more source

A concise assessment of salivary modifications in patients with chronic hepatitis [PDF]

Romanian Journal of Medical Practice, 2017
Background. Saliva is a complex biological fluid that has great potential as a diagnosis fluid for both oral and systemic diseases. At the same time, chronic hepatitis affects millions of people worldwide and can lead to liver cirrhosis and ...
Daniela-Gabriela BADITA, Dan PIPEREA-SIANU, Andra-Elena BALCANGIU-STROESCU, Bogdan CALENIC, Maria GREABU, Maria-Daniela TANASESCU, Laura RADUCU, Iulia-Ioana STANESCU   +7 more
doaj   +1 more source

Era of direct acting anti-viral agents for the treatment of hepatitis C. [PDF]

, 2018
Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone.
Ahmed, Monjur
core   +1 more source

Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study [PDF]

, 2018
Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure.
Akhan, S., Aydoǧdu, Ö., Baykam, N., Beslen, N., Bostanci, F., Candan, M., Daǧli, Ö., Demirdal, T., Duyar, E., Erdoǧan, S., Gökal, A.A., Güner, R., Gürbüz, Y., Inan, D., Kaya, A., Kaya, S., Kiliç, S., Kinikli, S., Kuruüzüm, Z., Kökoǧlu, Ö.F., Köksal, I., Leblebicioǧlu, H., Namiduru, M., Parlak, M., Sehmen, E., Tabak, F., Tarakçi, H., Turgut, Hüseyin, Ural, O., Yamazhan, T., Yilmaz, G., Yuluǧkural, Z., Önlen, Y., Özdemir, D., Özdener, F.   +34 more
core   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

BREAKTHROUGH ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS D

Актуальные проблемы теоретической и клинической медицины
For a long period of 46 years since the discovery of the hepatitis D virus antigen by M. Rizzetto in 1977, chronic hepatitis D was considered in conjunction with chronic hepatitis B, classified as chronic hepatitis B with the delta agent.
D. I. Otunbayeva, B. K. Nurgalieva, S. S. Kariyeva   +2 more
doaj   +1 more source

Perihepatic lymphadenopathy in children with chronic viral hepatitis

Journal of Ultrasonography, 2015
Objective. To assess whether lymph node enlargement in the hepatoduodenal ligament occurs in children with chronic viral hepatitis B and C in comparison to healthy controls. Subject and methods.
Dagmar Schreiber-Dietrich, Margret Pohl, Xin-Wu Cui, Barbara Braden, Christoph F. Dietrich, Liliana Chiorean   +5 more
doaj   +1 more source

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, a highly robust N‐glycoproteomics (HRN) platform with a newly developed match‐between‐run scheme is used for biomarker discovery. This study proposes a protein‐centric strategy to prioritize proteins susceptible to aberrant glycosylation.
Lei Liu, Taiheng Ma, Qi Liu, He Zhu, Zheng Fang, Jiahong Ma, Ting Yu, Yan Wang, Jiahua Zhou, Xiaoyan Liu, Yaqian Li, Zhimou Guo, Xinmiao Liang, Mingming Dong, Deguang Sun, Mingliang Ye   +15 more
wiley   +1 more source