AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Hepatology, EarlyView.
Robert J. Fontana+6 more
wiley +1 more source
CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang+18 more
wiley +1 more source
Chronic Hepatitis B Virus Persistence: Mechanisms and Insights. [PDF]
Naidu S, Margeridon S.
europepmc +1 more source
Immune Checkpoint Inhibitors and Cardiovascular Adverse Events
Abstract In the last years, we assisted to a tremendous increase in therapeutic options for the management of cancers, with immunotherapy at the forefront of this innovation. Immune checkpoint inhibitors (ICIs) have been developed to enhance the activity of the immune system against cancer cells (1) and the number of approvals for ICIs has rapidly ...
Maria Luisa De Perna+4 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam+10 more
wiley +1 more source
Drug development for chronic hepatitis B functional cure: Recent progress. [PDF]
Liu T+5 more
europepmc +1 more source
Recombinant alpha interferon for chronic hepatitis B in anti-HIV positive patients receiving zidovudine. [PDF]
Patrick Marcellin+7 more
openalex +1 more source
Acute myocarditis according to age: Presentation, management and early outcomes
MIS, multisystem inflammatory syndrome; MRE, myocarditis‐related events (within 30 days included all‐cause death, cardiogenic shock, cardiac arrest, ventricular arrhythmias or complete AV block). Abstract Aims Acute myocarditis (AM) is a rare but severe disease affecting patients of all ages. Large multicentric studies comparing children and adults are
Clément Karsenty+25 more
wiley +1 more source
A multiscale model of the action of a capsid assembly modulator for the treatment of chronic hepatitis B. [PDF]
Iyaniwura SA+3 more
europepmc +1 more source