Results 101 to 110 of about 259 (175)

CH50 as a Clinically Useful Biomarker of Disease Activity and Antihistamine Resistance in Chronic Spontaneous Urticaria: An Observational Ambispective Single‐Center Study

International Journal of Dermatology, EarlyView.
Personalized CSU care guided by CH50. ABSTRACT Background Chronic spontaneous urticaria (CSU) is frequently refractory to guideline‐based therapy, highlighting the need for predictive biomarkers. Dysregulation of the complement system has been implicated in CSU severity, but global complement activity has not been systematically evaluated.
Nidia Planella‐Fontanillas, Emilio Berna‐Rico, David Pesqué, Evelyn Andrades, Silvia Sánchez, Paloma Torres‐Bosó, Ramon Gimeno, Fernando Gallardo, Ramon M. Pujol, Ana M. Giménez‐Arnau   +9 more
wiley   +1 more source

Determination of perceived stress, salivary cortisol and interleukin-1β levels and clinical features of chronic urticaria in patients with dermographic urticaria in comparison to patients with chronic spontaneous urticaria and healthy individuals

Frontiers in Immunology
IntroductionAlthough dermographic urticaria or symptomatic dermographism (SD), is the most common chronic inducible urticaria subtype, little is known about its etiopathogenesis and associated factors such as psychological stress.MethodsIn this cross ...
Liborija Lugović-Mihić, Liborija Lugović-Mihić, Ina Novak-Hlebar, Ina Novak-Hlebar, Dajana Smoljan, Dajana Smoljan, Ines Vukasović, Ines Vukasović, Ema Barac, Maja Vilibić, Maja Vilibić   +10 more
doaj   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Advancements and challenges in the management of chronic inducible urticaria

Frontiers in Immunology
Chronic inducible urticaria (CIndU) is a group of diseases characterized by recurrent wheals and/or angioedema induced by specific triggers. Research into its underlying mechanisms remains underdeveloped, historically lagging behind that of chronic spontaneous urticaria (CSU).
Menghao Zhang, Juan Liu, Yuxiang Zhi
openaire   +1 more source

Parents' Experiences of Patient Safety Incidents During Their Child's Hospitalization: A Qualitative Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aims Patient safety incidents involving hospitalized children can have significant impacts on both patients and their families. However, previous research has primarily focused on healthcare professionals' perspectives, and studies exploring parents' experiences of patient safety incidents in paediatric settings remain limited.
Mi Young Kim, Yujeong Kim
wiley   +1 more source

Full‐Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open‐Label Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating, Y. Ogru, T. G. Duthy, L. Douglas, K. Lichkus, E. Isikgel, M. C. Fahey, C. Ellaway   +7 more
wiley   +1 more source

Evaluating Basophil Histamine Content as a Biomarker for Omalizumab Responsiveness in Chronic Spontaneous Urticaria

Clinical &Experimental Allergy, EarlyView.
Ditte Georgina Zhang, Katrine Baumann, Clive Grattan, Per Stahl Skov, Simon Francis Thomsen   +4 more
wiley   +1 more source

Optimising Asparaginase Use and Managing Hypersensitivity in Australasia—A Clinical Practice Guideline From the Australian and New Zealand Children's Haematology/Oncology Group

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Asparaginase is a critical component of modern multi‐agent chemotherapy regimens for paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma, with inadequate exposure leading to inferior patient outcomes. Objectives To develop a clinical practice guideline for the use of asparaginase products in the Australasian context.
Matthew J. O'Connor, Michelle Martin, Sarah M. Trinder, Draga Barbaric, Diane Hanna, Chow Y. Lai, Michael P. Osborn, Tim Prestige, Bryony Ross, Leanne Super, Thomas Walwyn, Stacie S. Wang, Andrew Wood, Andrew S. Moore, Rishi S. Kotecha, Siobhan Cross   +15 more
wiley   +1 more source

Contextual Learning of New Meanings for Familiar Words: Perturbation of Original Meanings Occurs Without Deliberate Study

Language Learning, EarlyView.
Abstract The present study investigated learning new meanings of known words from reading, following Hulme et al.’s (2018) study. English speakers read four short stories containing 16 critical words (i.e., familiar word forms assigned invented secondary meanings).
Nurul Aini Mohd Jelani, Irina Elgort
wiley   +1 more source

The effects of spectrum, irradiance, and duration of exposure on light‐induced melatonin suppression in healthy adults

Photochemistry and Photobiology, EarlyView.
The left panel reports the measured time course data of melatonin concentration in the blood plasma of 17 BL‐Rs and 15 BL‐NRs at baseline, during a two‐hour stay in the dark, during a one‐hour light exposure to blue light, and again in the dark. The right panel shows the magnitude of melatonin concentration after 60 min of exposure to warm white, cool ...
Helmut Piazena, Leonora Franke, Ralf Uebelhack, Thomas Penzel, Ingo Fietze   +4 more
wiley   +1 more source