Results 221 to 230 of about 1,336,163 (318)

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling. [PDF]

PLoS Pathog
Audibert A, Mas-Orea X, Rey L, Belloy M, Bassot E, Battut L, Marodon G, Masson F, Serino M, Cenac N, Dietrich G, Bonnart C, Blanchard N.   +12 more
europepmc   +1 more source

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of <i>Trypanosoma cruzi</i> Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model. [PDF]

J Med Chem
René O, Saldivia M, Dauphinais M, Zhang L, Hollingsworth SA, Jiricek J, Koester DC, Miller SL, Williams SL, Ng PS, Patra D, Jumani RS, Baxley GM, Osborne CS, Chen YB, Chen YL, Cheung H, Lakshminarayana SB, Galarneau JR, Diagana TT, Sarko C, Rao SPS.   +21 more
europepmc   +1 more source

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

The TLR7 agonist vesatolimod does not measurably induce SIV expression in macaques receiving combination antiretroviral therapy initiated during chronic infection. [PDF]

Antimicrob Agents Chemother
Swanstrom AE, Oswald K, Fast R, Shoemaker R, Thomas JA, Pyle C, Hull M, Bosche WJ, Li Y, Breed MW, Kramer JA, Donohue D, Trubey CM, Deleage C, Geleziunas R, Lifson JD, Del Prete GQ.   +16 more
europepmc   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Gfi1 controls the formation of effector-like CD8⁺ T cells during chronic infection and cancer. [PDF]

Nat Commun
Ojo OA, Shen H, Ingram JT, Bonner JA, Welner RS, Lacaud G, Zajac AJ, Shi LZ.   +7 more
europepmc   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Helicobacter pylori luxS mutants cause hyperinflammatory responses during chronic infection. [PDF]

Microbiol Spectr
Yang C, Rodriguez Y Baena A, Manso BA, Hu S, Lopez-Magaña R, Ohanyan M, Ottemann KM.   +6 more
europepmc   +1 more source