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Advanced Science, EarlyView.This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo +10 more
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Advanced Science, EarlyView.A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen +9 more
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Advanced Science, EarlyView.Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao +18 more
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Acute Kidney Disease to Chronic Kidney Disease
Critical Care Clinics, 2021Acute kidney injury (AKI) and chronic kidney disease are common interconnected syndromes that represent a public health problem. Acute kidney disease (AKD) is defined as the post-AKI status of acute or subacute kidney damage/dysfunction manifested by persistence of AKI beyond 7 to 90 days after the initial AKI diagnosis.
Javier A. Neyra, Lakhmir S. Chawla
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Deutsche medizinische Wochenschrift (1946), 2012
Chronic kidney disease is a general term for heterogeneous disorders affecting kidney structure and function. The 2002 guidelines for definition and classification of this disease represented an important shift towards its recognition as a worldwide public health problem that should be managed in its early stages by general internists.
M, Ketteler, C, Wanner
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Chronic kidney disease is a general term for heterogeneous disorders affecting kidney structure and function. The 2002 guidelines for definition and classification of this disease represented an important shift towards its recognition as a worldwide public health problem that should be managed in its early stages by general internists.
M, Ketteler, C, Wanner
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Medical Clinics of North America, 2005
Chronic kidney disease (CKD) is defined by the National Kidney Foundation (NKF) as either (1) a glomerular filtration rate (GFR) of 〈60 mL/min with or without kidney damage for 3 or more months or (2) the presence of kidney damage for 3 or more months demonstrated by pathologic abnormalities, markers of kidney damage (e.g., blood or urine composition),
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Chronic kidney disease (CKD) is defined by the National Kidney Foundation (NKF) as either (1) a glomerular filtration rate (GFR) of 〈60 mL/min with or without kidney damage for 3 or more months or (2) the presence of kidney damage for 3 or more months demonstrated by pathologic abnormalities, markers of kidney damage (e.g., blood or urine composition),
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2016
The term acute kidney injury (AKI) has replaced acute renal failure in contemporary medical literature. AKI denotes a rapid deterioration of kidney function within hours to weeks, resulting in the accumulation of nitrogenous metabolites in addition to fluid, electrolyte, and acid-base imbalances.
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The term acute kidney injury (AKI) has replaced acute renal failure in contemporary medical literature. AKI denotes a rapid deterioration of kidney function within hours to weeks, resulting in the accumulation of nitrogenous metabolites in addition to fluid, electrolyte, and acid-base imbalances.
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2010
Definition—chronic kidney disease (CKD) is defined as kidney damage lasting for more than 3 months characterized by structural or functional abnormalities of the kidney, with or without decreased glomerular filtration rate (GFR). Staging—CKD has been subdivided into five stages depending on the estimated GFR (eGFR), as described in ...
Eberhard Ritz, Tilman B. Drüeke
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Definition—chronic kidney disease (CKD) is defined as kidney damage lasting for more than 3 months characterized by structural or functional abnormalities of the kidney, with or without decreased glomerular filtration rate (GFR). Staging—CKD has been subdivided into five stages depending on the estimated GFR (eGFR), as described in ...
Eberhard Ritz, Tilman B. Drüeke
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Chronic kidney disease and kidney stones
Current Opinion in Nephrology and Hypertension, 2020Both chronic kidney disease (CKD) and kidney stones are major public health problems, which are closely interrelated. Recurrent kidney stones predispose to CKD although CKD seems to decrease risk of further kidney stone formation. Herein, we review new information of this interrelationship.Several epidemiological studies in the past have shown an ...
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Allopurinol and Chronic Kidney Disease
New England Journal of Medicine, 2020Natalie McCormick +2 more
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