Results 61 to 70 of about 690,557 (312)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses

Frontiers in Microbiology
BackgroundAlcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses the therapeutic potential of combining Akkermansia muciniphila (A.
Li Wei, Yizhi Pan, Yu Guo, Yin Zhu, Yin Zhu, Haoran Jin, Yingying Gu, Chuanshuang Li, Yaqin Wang, Jingjing Lin, Yongping Chen, Chunhai Ke, Chunhai Ke, Lanman Xu, Lanman Xu   +14 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Global Burden of Major Chronic Liver Diseases in 2021

Background: This study utilised the Global Burden of Disease data (2010–2021) to analyse the rates and trends in point prevalence, annual incidence and years lived with disability (YLDs) for major chronic liver diseases, such as hepatitis B, hepatitis C,
Seto, Wai-Kay, Zheng, Ming-Hua, Pan, Calvin Q., Yılmaz, Yusuf, Valenti, Luca, Méndez-Sánchez, Nahum, Feng, Gong   +6 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Nicotine exacerbates MASH via inducing intestinal dysbiosis and barrier dysfunction

Communications Biology
Nicotine accumulation in the intestine is associated with an exacerbation of metabolic dysfunction-associated steatohepatitis (MASH), but the underlying mechanisms remain enigmatic.
Fangfang Yi, Jinyong Wang, Yi Chen, Yuanhang Xia, Hongfei Zhou, Yilun Huang, Yujuan Shen, Sizhe Fang, Xiaodong Wang, Ya Zhang, Yongping Chen, Dazhi Chen   +11 more
doaj   +1 more source

Impact of gut microbiota on nonalcoholic fatty liver disease: insights from a leave-one-out cross-validation study

Frontiers in Microbiology
IntroductionEnteric dysbacteriosis is strongly associated with nonalcoholic fatty liver disease (NAFLD). However, the underlying causal relationship remains unknown. Thus, the present study aimed to investigate the relationship between gut microbiota and
Tongtong Pan, Lihuang Su, Yiying Zhang, Fangfang Yi, Yongping Chen   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nutrition in Chronic Liver Disease

GE Portuguese Journal of Gastroenterology, 2015
Protein-calorie malnutrition is a transversal condition to all stages of chronic liver disease. Early recognition of micro or macronutrient deficiencies is essential, because the use of nutritional supplements reduces the risk of complications. The diet of patients with chronic liver disease is based on a standard diet with supplements addition as ...
Silva,Marco, Gomes,Sara, Peixoto,Armando, Torres-Ramalho,Paulo, Cardoso,Hélder, Azevedo,Rosa, Cunha,Carla, Macedo,Guilherme   +7 more
openaire   +4 more sources

Cryptosporidiosis in patients with diarrhea and chronic liver diseases

Journal of Infection in Developing Countries, 2014
Introduction: The aim of this study was to evaluate the epidemiology and clinical significance of Cryptosporidium in patients with diarrhea and chronic liver diseases. Methodology: The study included 150 patients with chronic liver diseases and diarrhea,
Nasser Mousa, Ahmed Abdel-Razik, Hala El-Nahas, Atef El-Shazly, Mohammad Abdelaziz, Marwa Nabih, Magdy Hamed, Mohammad Eissa, Narmin Effat, Walled Eldars   +9 more
doaj   +1 more source