Results 151 to 160 of about 12,027,294 (272)

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Task-evoked network connectivity and pain regulation success in chronic low back pain. [PDF]

Neuroimage Rep
Anderson SR, Gilam G, Law C, Weber KA, Goldin PR, Wager TD, Kong JT, Darnall BD, Gross JJ, Mackey SC.   +9 more
europepmc   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Prevalence and competing risk of psychiatric comorbidities in chronic low back pain by age group. [PDF]

Pain Rep
Pontiff RJ, Helm A, Milani SA, Morrow M, Tucker CA.   +4 more
europepmc   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Comparison of the Effects of Kinesio Taping and Foam Roller Exercises in Individuals with Non-Specific Chronic Low Back Pain. [PDF]

Healthcare (Basel)
Cicekler ME, Genc H, Demircioglu G, Burma K.   +3 more
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Weight management for chronic low back pain. [PDF]

Cochrane Database Syst Rev
Mudd E, Tutty A, Kamper SJ, Cashin AG, Michaleff ZA, Davidson SR, Alves E, Browne S, Linton J, McAuley JH, Williams CM.   +10 more
europepmc   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source