Results 1 to 10 of about 37,409 (221)

Influence of mycophenolate mofetil dosage and plasma levels on the occurrence of chronic lung allograft dysfunction in lung transplants: a retrospective cohort analysis [PDF]

Swiss Medical Weekly, 2022
INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite ...
Carolin Steinack, Philipp Saurer, Fiorenza Gautschi, René Hage, Gernot Ortmanns, Macé M. Schuurmans, Thomas Gaisl   +6 more
doaj   +4 more sources

Systems prediction of chronic lung allograft dysfunction: Results and perspectives from the Cohort of Lung Transplantation and Systems prediction of Chronic Lung Allograft Dysfunction cohorts [PDF]

Frontiers in Medicine, 2023
BackgroundChronic lung allograft dysfunction (CLAD) is the leading cause of poor long-term survival after lung transplantation (LT). Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) aimed to predict CLAD.MethodsTo predict CLAD, we ...
Christophe Pison, Christophe Pison, Adrien Tissot, Adrien Tissot, Eric Bernasconi, Pierre-Joseph Royer, Antoine Roux, Antoine Roux, Angela Koutsokera, Benjamin Coiffard, Benjamin Renaud-Picard, Benjamin Renaud-Picard, Jérôme Le Pavec, Pierre Mordant, Xavier Demant, Thomas Villeneuve, Jean-Francois Mornex, Jean-Francois Mornex, Simona Nemska, Nelly Frossard, Olivier Brugière, Olivier Brugière, Valérie Siroux, Benjamin J. Marsland, Benjamin J. Marsland, Aurore Foureau, Aurore Foureau, Karine Botturi, Eugenie Durand, Johann Pellet, Richard Danger, Charles Auffray, Sophie Brouard, Laurent Nicod, Antoine Magnan, Antoine Magnan, Members of the Cohort of Lung Transplantation and Systems prediction of Chronic Lung Allograft Dysfunction consortia   +36 more
doaj   +3 more sources

The Association of Post-Lung Transplant Pulmonary Embolism With the Development of Chronic Lung Allograft Dysfunction. [PDF]

Transplant Direct
Background. Pulmonary embolism (PE) is a rare yet serious postoperative complication for lung transplant recipients (LTRs). The association between timing and severity of PE and the development of chronic allograft lung dysfunction (CLAD) has not been ...
Magin JC, Xu C, Peskoe S, Dorry M, Frankel CW, Dahhan T, Snyder LD.   +6 more
europepmc   +3 more sources

Metformin attenuates chronic lung allograft dysfunction: evidence in rat models [PDF]

Respiratory Research, 2023
Background Chronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after lung transplantation (LTx), but effective and safe drugs are not available.
Dong Tian, Xiangyun Zheng, Hongtao Tang, Heng Huang, Junjie Wang, Lin Xu, Caihan Li, Haoji Yan, Ruixuan Yu, Jinzhu Nan, Menggen Liu, Xiaoguang Guo, Shunhai Jian, Tao Wang, Senyi Deng, Qiang Pu, Lunxu Liu   +16 more
doaj   +3 more sources

Blood MMP-9 measured at 2 years after lung transplantation as a prognostic biomarker of chronic lung allograft dysfunction. [PDF]

Respir Res
Background Long-term outcomes of lung transplantation (LTx) remain hampered by chronic lung allograft dysfunction (CLAD). Matrix metalloproteinase 9 (MMP-9) is a secretory endopeptidase identified as a key mediator in fibrosis processes associated with ...
Tissot A, Durand E, Goronflot T, Coiffard B, Renaud-Picard B, Roux A, Demant X, Mornex JF, Falque L, Salpin M, Le Pavec J, Villeneuve T, Boussaud V, Knoop C, Magnan A, Lair D, Berthelot L, Danger R, Brouard S, COLT consortium.   +19 more
europepmc   +4 more sources

JAK-STAT activation contributes to cytotoxic T cell-mediated basal cell death in human chronic lung allograft dysfunction. [PDF]

JCI Insight, 2023
Chronic lung allograft dysfunction (CLAD) is the leading cause of death in lung transplant recipients. CLAD is characterized clinically by a persistent decline in pulmonary function and histologically by the development of airway-centered fibrosis known ...
Khatri A, Todd JL, Kelly FL, Nagler A, Ji Z, Jain V, Gregory SG, Weinhold KJ, Palmer SM.   +8 more
europepmc   +4 more sources

Diagnosis and Treatment of Fungal Infections in Lung Transplant Recipients [PDF]

Pathogens, 2023
Fungal infections are a significant source of morbidity in the lung transplant population via direct allograft damage and predisposing patients to the development of chronic lung allograft dysfunction.
Jesus E. Escamilla, Spenser E. January, Rodrigo Vazquez Guillamet   +2 more
doaj   +3 more sources

A European Multi-Center Analysis of Extracorporeal Photopheresis as Therapy for Chronic Lung Allograft Dysfunction. [PDF]

Transpl Int, 2023
Extracorporeal photopheresis (ECP) is used by few lung transplant centers to treat chronic lung allograft dysfunction (CLAD). Although reported results suggest a beneficial effect on CLAD progression, evidence is limited to single center experiences. The
Benazzo A, Bagnera C, Ius F, Del Fante C, Gottlieb J, Hoetzenecker K, Meloni F, Jaksch P, Greer M.   +8 more
europepmc   +2 more sources

Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. [PDF]

, 2017
BackgroundChronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD is usually not responsive to treatment, earlier identification may improve treatment prospects.MethodsIn a nested ...
Ardehali, Abbas, Belperio, John A, Birjandi, Shirin, DerHovanessian, Ariss, Elashoff, David, Gregson, Aric L, Lynch, Joseph P, Palchevskiy, Vyacheslav, Palmer, Scott M, Patel, Naman, Ross, David J, Saggar, Rajan, Sayah, David M, Shino, Michael Y, Wang, Xiaoyan, Weigt, S Samuel   +15 more
core   +6 more sources

Monogenic gene variants in lung transplant recipients with usual interstitial pneumonia [PDF]

ERJ Open Research, 2022
Aim The prevalence of monogenic disease-causing gene variants in lung transplant recipients with idiopathic pulmonary fibrosis is not fully known. Their impact on clinical outcomes before and after transplantation requires more evidence.
Christoffer Stark, Juha W. Koskenvuo, Antti Nykänen, Eija H. Seppälä, Samuel Myllykangas, Karl Lemström, Peter Raivio   +6 more
doaj   +3 more sources