Chronic lung allograft dysfunction. [PDF]
Indian J Thorac Cardiovasc Surg, 2022 Lung transplantation remains the only cure for selected patients with advanced irreversible lung diseases. More than 4000 lung transplants are performed worldwide annually.
Kumar A, Garcha PS.
europepmc +9 more sources
Everolimus Treatment for Chronic Lung Allograft Dysfunction in Lung Transplantation [PDF]
LifeOur study aims to evaluate the effect of everolimus treatment on lung function in lung transplant (LT) patients with established chronic lung allograft dysfunction (CLAD).
David Iturbe-Fernández +7 more
doaj +5 more sources
ALEMTUZUMAB FOR CHRONIC LUNG ALLOGRAFT DYSFUNCTION [PDF]
Chest, 2020 SESSION TITLE: Transplantation Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: Chronic lung allograft dysfunction (CLAD) remains the leading cause of long-term mortality after lung transplantation (LTX) with no proven therapeutic strategies except re-transplantation Anecdotal reports suggest a role for ...
Reda E. Girgis +7 more
europepmc +5 more sources
Microbiome and metabolome patterns after lung transplantation reflect underlying disease and chronic lung allograft dysfunction. [PDF]
MicrobiomeBackground Progression of chronic lung disease may lead to the requirement for lung transplant (LTx). Despite improvements in short-term survival after LTx, chronic lung allograft dysfunction (CLAD) remains a critical challenge for long-term survival ...
Martin C +6 more
europepmc +2 more sources
Early chest CT abnormalities to predict the subsequent occurrence of chronic lung allograft dysfunction. [PDF]
Insights Imaging, 2023 Introduction Chronic lung allograft dysfunction (CLAD) can take two forms: bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS).
Habert P +8 more
europepmc +2 more sources
Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction. [PDF]
Pharmacol Rev, 2023 Chronic lung rejection, also called chronic lung allograft dysfunction (CLAD), remains the major hurdle limiting long-term survival after lung transplantation, and limited therapeutic options are available to slow the progressive decline in lung function.
Bos S +6 more
europepmc +2 more sources
Chronic Lung Allograft Dysfunction Is Associated with Significant Disability after Lung Transplantation-A Burden of Disease Analysis in 1025 Cases. [PDF]
Adv Respir Med, 2023 Highlights What are the main findings? One out of four lung transplant recipients in the largest German center develop chronic lung allograft dysfunction (CLAD), which corresponds to chronic lung transplant rejection.
Diel R, Simon S, Gottlieb J.
europepmc +2 more sources
Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle [PDF]
European Respiratory Review, 2022 Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has
Saskia Bos +4 more
doaj +2 more sources
MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction. [PDF]
J Clin InvestTissue fibrosis remains unamenable to meaningful therapeutic interventions and is the primary cause of chronic graft failure after organ transplantation.
Walker NM +10 more
europepmc +2 more sources
Humoral immune responses mediate the development of a restrictive phenotype of chronic lung allograft dysfunction [PDF]
JCI Insight, 2020 Understanding the distinct pathogenic mechanisms that culminate in allograft fibrosis and chronic graft failure is key in improving outcomes after solid organ transplantation.
Keizo Misumi +13 more
doaj +2 more sources