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Chronic lung allograft dysfunction after lung transplantation
2023Chronic lung allograft dysfunction (CLAD) remains one of the most important complications after lung transplantation, affecting 50% of patients by 5 years post-transplant. It is a major cause of morbidity and the leading cause of mortality beyond 5 years after the transplantation procedure.
Gimenez, Berta Saez +4 more
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Chronic lung allograft dysfunction
Current Respiratory Care Reports, 2014The recognition that chronic graft dysfunction after lung transplantation is a heterogeneous phenomenon has led to the introduction of a new term: chronic lung allograft dysfunction (CLAD). An International Society for Heart and Lung Transplantation working group will determine a definition of CLAD in 2014.
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Chronic Lung Allograft Dysfunction: Evolving Concepts and Therapies
Seminars in Respiratory and Critical Care Medicine, 2018Abstract Lung transplantation has become an established therapeutic option for a variety of end-stage lung diseases. Technical advances in graft procurement, implantation, perioperative care, immunosuppression, and posttransplant medical management have led to significant improvements in 1-year survival, but outcomes after the first ...
Ariss, DerHovanessian +4 more
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Fungal Prophylaxis and Chronic Lung Allograft Dysfunction
The Journal of Heart and Lung Transplantation, 2020Purpose Prior studies demonstrate that lung transplant recipients (LTRs) experience the highest rate of invasive mold infections amongst all transplant recipients. Aspergillosis is the most common offender, and aspergillus colonization and invasive disease have been linked to chronic lung allograft dysfunction (CLAD).
S.L. Beach +10 more
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Airway Alterations in Chronic Lung Allograft Dysfunction
The Journal of Heart and Lung Transplantation, 2014s S105 M. Rivera-Otero, A. Salvador-Sanz. Cardiology Department. Hert Failure and Transplantation Unit, Hospital Universitari i Politecnic La Fe,
S.E. Verleden +17 more
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Clinics in chest medicine, 2023
Lung transplantation is an established treatment of well-selected patients with end-stage respiratory diseases. However, lung transplant recipients have the highest rates of acute and chronic rejection among transplanted solid organs. Owing to ongoing alloimmune recognition and associated immune-driven airway/vascular remodeling, precipitated by ...
Hanne, Beeckmans +3 more
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Lung transplantation is an established treatment of well-selected patients with end-stage respiratory diseases. However, lung transplant recipients have the highest rates of acute and chronic rejection among transplanted solid organs. Owing to ongoing alloimmune recognition and associated immune-driven airway/vascular remodeling, precipitated by ...
Hanne, Beeckmans +3 more
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Chronic lung allograft dysfunction after lung transplantation: the moving target
General Thoracic and Cardiovascular Surgery, 2012Chronic lung allograft dysfunction is a major challenge in long-term management of lung transplant recipients. Both alloimmune-dependent factors (rejection) and alloimmune-independent factors contribute to the development of chronic lung allograft dysfunction. Thus, use of the term "chronic rejection" tends to be intentionally avoided among specialists
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Chronic lung allograft dysfunction
Transplantation Reviews, 1998Hélène Levrey, Marshall I. Hertz
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