Results 221 to 230 of about 37,459 (257)

Percentage of low attenuation area on computed tomography detects chronic lung allograft dysfunction, especially bronchiolitis obliterans syndrome, after bilateral lung transplantation

Clinical Transplantation, 2023
The percentage of low attenuation area (%LAA) on computed tomography (CT) is useful for evaluating lung emphysema, and higher %LAA was observed in patients with chronic lung allograft dysfunction (CLAD).
Y. Kubo, S. Sugimoto, T. Shiotani, K. Matsubara, K. Hashimoto, S. Tanaka, K. Shien, K. Suzawa, K. Miyoshi, H. Yamamoto, M. Okazaki, S. Toyooka   +11 more
semanticscholar   +1 more source

Chronic lung allograft dysfunction

Current Opinion in Organ Transplantation, 2015
Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection.
Robin Vos, Geert Verleden, Stijn E. Verleden   +2 more
openaire   +3 more sources

Prognosis and Risks for Probable Chronic Lung Allograft Dysfunction: A Prospective Multicenter Study.

American Journal of Respiratory and Critical Care Medicine
RATIONALE Chronic lung allograft dysfunction (CLAD) hinders lung transplant success. A 2019 consensus refined CLAD diagnosis, introducing probable or definite CLAD based on persistence of lung function decline. Outcomes and risks for probable CLAD remain
J. Todd, S. Weigt, Megan L Neely, Maria V. Grau‐Sepulveda, Kristen Mason, Michelle L Sever, Karen Kesler, Jerry Kirchner, C. Frankel, Tereza Martinu, M. Shino, Annette M Jackson, E. Pavlisko, Nikki M Williams, M. Robien, L. Singer, M. Budev, W. Tsuang, P. Shah, John M. Reynolds, Laurie D. Snyder, J. Belperio, Scott M. Palmer   +22 more
semanticscholar   +1 more source

Pharmacotherapy of chronic lung allograft dysfunction post lung transplantation

Clinical Transplantation, 2022
AbstractBackgroundChronic lung allograft dysfunction (CLAD) remains the primary cause of death in lung transplant recipients (LTRs) despite improvements in immunosuppression management. Despite advances in knowledge regarding the pathogenesis of CLAD, treatments that are currently available are usuallyineffective and delay progression of disease at ...
Rickey A. Evans, Krysta S. Walter, Leonard Jason Lobo, Raymond Coakley, Christina T. Doligalski   +4 more
openaire   +2 more sources

Chronic Lung Allograft Dysfunction: Evolving Concepts and Therapies

Seminars in Respiratory and Critical Care Medicine, 2018
AbstractThe primary factor that limits long-term survival after lung transplantation is chronic lung allograft dysfunction (CLAD). CLAD also impairs quality of life and increases the costs of medical care. Our understanding of CLAD continues to evolve. Consensus definitions of CLAD and the major CLAD phenotypes were recently updated and clarified, but ...
Joseph P. Lynch, Olawale Amubieya, S. Samuel Weigt, Gregory A. Fishbein, John A. Belperio, Ariss Derhovanessian, Allison Ramsey   +6 more
openaire   +4 more sources

Fungal Prophylaxis and Chronic Lung Allograft Dysfunction

The Journal of Heart and Lung Transplantation, 2020
Purpose Prior studies demonstrate that lung transplant recipients (LTRs) experience the highest rate of invasive mold infections amongst all transplant recipients. Aspergillosis is the most common offender, and aspergillus colonization and invasive disease have been linked to chronic lung allograft dysfunction (CLAD).
John A. Belperio, S.L. Beach, Rajan Saggar, Joanna Schaenman, Allison Ramsey, Ariss Derhovanessian, Joseph P. Lynch, Y.M. Shino, Abbas Ardehali, S. Sam Weigt, David M. Sayah   +10 more
openaire   +2 more sources

Chronic lung allograft dysfunction after lung transplantation

2023
Chronic lung allograft dysfunction (CLAD) remains one of the most important complications after lung transplantation, affecting 50% of patients by 5 years post-transplant. It is a major cause of morbidity and the leading cause of mortality beyond 5 years after the transplantation procedure.
Gimenez, Berta Saez, Hellemons, Merel, Verleden, Stijn E., Gottlieb, Jens, Verleden, Geert M.   +4 more
openaire   +1 more source

Chronic Lung Allograft Dysfunction: Clinical Manifestations and Immunologic Mechanisms

Transplantation
The term “chronic lung allograft dysfunction” has emerged to describe the clinical syndrome of progressive, largely irreversible dysfunction of pulmonary allografts.
Amit I. Bery, Natalia Belousova, R. Hachem, Antoine Roux, Daniel Kreisel   +4 more
semanticscholar   +1 more source

Impact of Angiotensin Blockade on Development of Chronic Lung Allograft Dysfunction

Journal of pharmacy and practice, 2023
Background: The renin-angiotensin-aldosterone system (RAAS) is responsible for a multitude of physiological functions, including immunological effects such as promotion of TGF-β and upregulation of IL-6 and IL-8 which are also implicated in the ...
S. January, Julie Hubbard, K. Fester, Casey A Dubrawka, R. Vazquez Guillamet, H. Kulkarni, R. Hachem   +6 more
semanticscholar   +1 more source

Monitoring practices of chronic lung allograft dysfunction in pediatric lung transplantation

Pediatric Pulmonology, 2022
AbstractIntroductionChronic lung allograft dysfunction (CLAD) continues to negatively impact the survival of pediatric lung transplant (LTx) recipients. Current consensus guidelines are adult‐focused. We sought to examine CLAD detection and monitoring practices at pediatric LTx programs.MethodsWe conducted a survey among the International Pediatric ...
Avdimiretz, Nicholas, Radtke, Thomas, Benden, Christian   +2 more
openaire   +2 more sources