Results 21 to 30 of about 24,300 (246)

High-dimensional flow cytometry reveals lymphocyte subset populations predictive of chronic lung allograft dysfunction. [PDF]

Clin Transl Immunology
Farighi R, Hiho S, Ashhurst T, Edwards ES, Sullivan L, van Zelm MC, Snell G, Westall G, Tarlinton DM, Zotos D.   +9 more
europepmc   +3 more sources

Systems prediction of chronic lung allograft dysfunction: Results and perspectives from the Cohort of Lung Transplantation and Systems prediction of Chronic Lung Allograft Dysfunction cohorts. [PDF]

Front Med (Lausanne), 2023
BackgroundChronic lung allograft dysfunction (CLAD) is the leading cause of poor long-term survival after lung transplantation (LT). Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) aimed to predict CLAD.MethodsTo predict CLAD, we ...
Pison C, Tissot A, Bernasconi E, Royer PJ, Roux A, Koutsokera A, Coiffard B, Renaud-Picard B, Le Pavec J, Mordant P, Demant X, Villeneuve T, Mornex JF, Nemska S, Frossard N, Brugière O, Siroux V, Marsland BJ, Foureau A, Botturi K, Durand E, Pellet J, Danger R, Auffray C, Brouard S, Nicod L, Magnan A, Members of the Cohort of Lung Transplantation and Systems prediction of Chronic Lung Allograft Dysfunction consortia.   +27 more
europepmc   +2 more sources

Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle

European Respiratory Review, 2022
Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has
Saskia Bos, Luke Milross, Andrew J. Filby, Robin Vos, Andrew J. Fisher   +4 more
doaj   +1 more source

Prognostic impact of restrictive ventilatory defects in chronic lung allograft dysfunction without restrictive allograft syndrome-like opacities: Stratification of emerging undefined and unclassified phenotypes. [PDF]

JHLT Open
Background: Chronic lung allograft dysfunction (CLAD) remains a critical factor affecting post-lung transplant prognosis. While RAS-like opacities (RLO) are established as poor prognostic indicators, prognostic stratification of non-RLO CLAD cases ...
Fukuda T, Nakamura Y, Ko Y, Tseng SC, Gagne SM, Johkoh T, Li Y, Christiani DC, Ojiri H, Sholl L, Nishino M, Hatabu H.   +11 more
europepmc   +2 more sources

Downregulation of Tumor Suppressor Gene LKB1 During Severe Primary Graft Dysfunction After Human Lung Transplantation: Implication for the Development of Chronic Lung Allograft Dysfunction. [PDF]

Transplantation
Rahman M, Scozzi D, Eguchi N, Klein R, Sankpal NV, Sureshbabu A, Fleming T, Hachem R, Smith M, Bremner R, Mohanakumar T.   +10 more
europepmc   +3 more sources

Metformin attenuates chronic lung allograft dysfunction: evidence in rat models. [PDF]

Respir Res, 2023
Background Chronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after lung transplantation (LTx), but effective and safe drugs are not available.
Tian D, Zheng X, Tang H, Huang H, Wang J, Xu L, Li C, Yan H, Yu R, Nan J, Liu M, Guo X, Jian S, Wang T, Deng S, Pu Q, Liu L.   +16 more
europepmc   +2 more sources

Gastroesophageal Reflux in Lung Transplantation

Barcelona Respiratory Network Reviews, 2023
Gastroesophageal reflux disease (GERD) in lung transplant recipients has been associated with chronic lung allograft dysfunction (CLAD). CLAD is a leading cause of mortality in lung transplant recipients, and it is probably the result of a variety of ...
Sheila Izquierdo-Cuervo, Sandra Tello-Mena, Víctor M. Mora-Cuesta   +2 more
doaj   +1 more source

Humoral immune responses mediate the development of a restrictive phenotype of chronic lung allograft dysfunction [PDF]

JCI Insight, 2020
Understanding the distinct pathogenic mechanisms that culminate in allograft fibrosis and chronic graft failure is key in improving outcomes after solid organ transplantation.
Keizo Misumi, David Wheeler, Yoshiro Aoki, M.P. Combs, Russell R. Braeuer, Ryuji Higashikubo, Wenjun Li, Daniel Kreisel, Ragini Vittal, Jeffrey L. Myers, Amir Lagstein, Natalie Walker, Carol Farver, Vibha N. Lama   +13 more
openalex   +2 more sources

Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. [PDF]

, 2017
BackgroundChronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD is usually not responsive to treatment, earlier identification may improve treatment prospects.MethodsIn a nested ...
Ardehali, Abbas, Belperio, John A, Birjandi, Shirin, DerHovanessian, Ariss, Elashoff, David, Gregson, Aric L, Lynch, Joseph P, Palchevskiy, Vyacheslav, Palmer, Scott M, Patel, Naman, Ross, David J, Saggar, Rajan, Sayah, David M, Shino, Michael Y, Wang, Xiaoyan, Weigt, S Samuel   +15 more
core   +5 more sources

An update on chronic lung allograft dysfunction [PDF]

Annals of Translational Medicine, 2020
Chronic lung allograft dysfunction (CLAD) remains a significant challenge and the major determinant of morbidity and mortality post lung transplantation (LTx). The definition of CLAD has evolved significantly over the last ten years, reflecting better understanding of pathophysiology and different phenotypes. While there is an agreed consensus approach
Kotecha, Sakhee, Paraskeva, Miranda A., Levin, Kovi, Snell, Gregory I.   +3 more
openaire   +2 more sources