Results 51 to 60 of about 37,459 (257)

Update on Chronic Lung Allograft Dysfunction [PDF]

Current Transplantation Reports, 2016
Chronic lung allograft dysfunction (CLAD) encompasses a range of pathologies that cause a transplanted lung to not achieve or maintain normal function. CLAD manifests as airflow restriction and/or obstruction and is predominantly a result of chronic rejection.
Ramsey R. Hachem, Jason M. Gauthier, Daniel Kreisel   +2 more
openaire   +3 more sources

Antifibrotic drugs in lung transplantation and chronic lung allograft dysfunction: a review [PDF]

European Respiratory Review, 2021
This review aims to provide an overview of pre-transplant antifibrotic therapy on peri-transplant outcomes and to address the possible role of antifibrotics in lung transplant recipients with chronic lung allograft dysfunction.Lung transplantation is an established treatment modality for patients with various end-stage lung diseases, of which ...
Saskia Bos, Laurens J. De Sadeleer, Arno Vanstapel, Hanne Beeckmans, Annelore Sacreas, Jonas Yserbyt, Wim A. Wuyts, Robin Vos   +7 more
openaire   +3 more sources

Chronic Lung Allograft Dysfunction [PDF]

Transplantation, 2016
Chronic lung allograft dysfunction (CLAD) is the major limitation of long-term survival after lung transplantation. Chronic lung allograft dysfunction manifests as bronchiolitis obliterans syndrome or the recently described restrictive allograft syndrome.
Pierre-Joseph Royer, Laurent P. Nicod, Jean-Pierre Boissel, Christophe Pison, Christophe Pison, Christophe Pison, Eric Bernasconi, John-David Aubert, Angela Koutsokera, Gustavo Olivera-Botello, Adrien Tissot, Antoine Magnan   +11 more
openaire   +5 more sources

Chronic lung allograft dysfunction phenotypes and treatment [PDF]

Journal of Thoracic Disease, 2017
Chronic lung allograft dysfunction (CLAD) remains a major hurdle limiting long-term survival post lung transplantation. Given the clinical heterogeneity of CLAD, recently two phenotypes of CLAD have been defined [bronchiolitis obliterans syndrome (BOS) vs. restrictive allograft syndrome (RAS) or restrictive CLAD (rCLAD)].
Verleden, Stijn, Vos, Robin, Vanaudenaerde, Bart, Verleden, Geert   +3 more
openaire   +3 more sources

Determining Clinical Thresholds for Donor HLA Eplet Compatibility to Predict Best Outcomes Following Lung Transplantation

Transplantation Direct, 2022
Background. Currently, the assessment of immunological risk in lung transplantation (LTx) does not completely consider HLA compatibility at the molecular level.
Steven J. Hiho, BSc, Duncan C. Walton, BSc, Miranda A. Paraskeva, MD, Bronwyn J. Levvey, RN, Mary B. Diviney, BSc, Gregory I. Snell, MD, Lucy C. Sullivan, PhD, Glen P. Westall, MD   +7 more
doaj   +1 more source

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]

, 2017
Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L, Reed, Elaine F, Thomas, Kimberly A, Valenzuela, Nicole M   +3 more
core   +4 more sources

Survival After Lung Transplantation for Chronic Hypersensitivity Pneumonitis: Results From a Large International Cohort Study [PDF]

, 2022
Repeated exposure to antigens via inhalation is the primary cause of hypersensitivity pneumonitis, a form of interstitial pneumonia. The chronic form of hypersensitivity pneumonitis leads to progressive loss of respiratory function; lung transplantation ...
Alvarez A., Casado P. M., Ceulemans L., D'Ovidio F., Ehrsam J., Inci I., Keshavjee S., Krueger T., Leiva-Juarez M., Luzzi L., Nosotti M., Paladini P., Rackauskas M., Rea F., Rosso L., Roth A., Schiavon M., Van Raemdonck D.   +17 more
core   +6 more sources

Coronavirus and Chronic Lung Allograft Dysfunction: Hiding in Plain Sight?

Transplantation Direct, 2018
Alicia B. Mitchell, BMedSc(Hons), Allan R. Glanville, MD   +1 more
doaj   +4 more sources

Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival. [PDF]

, 2019
Standard methods for detecting chronic lung allograft dysfunction (CLAD) and rejection have poor sensitivity and specificity and have conventionally required bronchoscopies and biopsies.
Damm, Izabella, Liberto, Juliane M, Sarwal, Minnie M, Sarwal, Reuben D, Sigdel, Tara K, Vanaudenaerde, Bart M, Verleden, Geert M, Verleden, Stijn E, Vos, Robin, Watson, Drew, Yang, Joshua YC, Zarinsefat, Arya   +11 more
core   +2 more sources

The potential of biomarkers of fibrosis in chronic lung allograft dysfunction [PDF]

Transplantation Reviews, 2021
Chronic lung allograft dysfunction (CLAD) is the major long-term cause of morbidity and mortality after lung transplantation. Both bronchiolitis obliterans syndrome and restrictive lung allograft syndrome, two main types of CLAD, lead to fibrosis in either the small airways or alveoli and pleura.
Janette K. Burgess, Janette K. Burgess, Eline A van der Ploeg, C Tji Gan, Barbro N. Melgert, Barbro N. Melgert   +5 more
openaire   +2 more sources