Results 61 to 70 of about 24,300 (246)

Infectious Triggers of Chronic Lung Allograft Dysfunction [PDF]

Current Infectious Disease Reports, 2016
Survival after lung transplantation is limited in large part due to the high incidence of chronic rejection, known as chronic lung allograft dysfunction (CLAD). Pulmonary infections are a frequent complication in lung transplant recipients, due both to immunosuppressive medications and constant exposure of the lung allograft to the external environment
openaire   +2 more sources

Host–Pathogen Interactions and Chronic Lung Allograft Dysfunction [PDF]

Annals of the American Thoracic Society, 2017
Lung transplantation is now considered to be a therapeutic option for patients with advanced-stage lung diseases. Unfortunately, due to post-transplant complications, both infectious and noninfectious, it is only a treatment and not a cure. Infections (e.g., bacterial, viral, and fungal) in the immunosuppressed lung transplant recipient are a common ...
Belperio, John, Palmer, Scott M, Weigt, S Sam   +2 more
openaire   +4 more sources

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Using a combination of biomarkers to monitor allograft dysfunction in lung transplant recipients

Frontiers in Transplantation
Allograft dysfunction is a major limitation of survival in organ transplant recipients including those who have received lung transplantation. Early detection of allograft dysfunction is thus crucial to improve outcomes in these patients.
Zein Kattih, Shambhu Aryal
doaj   +1 more source

Thoracic Ultrasound in Lung Transplantation—Insights in the Field

Life, 2023
The use of thoracic ultrasound (TUS) is a novel and dynamic diagnostic and monitoring modality that has shown remarkable advances within the last decade, with several published papers investigating its role within the field of lung transplantation.
Hans Henrik Lawaetz Schultz, Jesper Rømhild Davidsen   +1 more
doaj   +1 more source

Rattus Model Utilizing Selective Pulmonary Ischemia Induces Bronchiolitis Obliterans Organizing Pneumonia [PDF]

, 2013
Bronchiolitis obliterans organizing pneumonia (BOOP), a morbid condition when associated with lung transplant and chronic lung disease, is believed to be a complication of ischemia.
Clough, Anne V., Cummens, Breana, Densmore, John C., Jacobs, Elizabeth R., Jeziorczak, Paul M., Medhora, Meetha, Pritchard, Kirkwood A., Jr, Rao, Arjun   +7 more
core   +2 more sources

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Montelukast in chronic lung allograft dysfunction after lung transplantation

The Journal of Heart and Lung Transplantation, 2019
Chronic lung allograft dysfunction (CLAD) is a major cause of post‒lung transplant mortality, with limited medical treatment options. In this study we assessed the association of montelukast treatment with pulmonary function and outcome in lung transplant recipients with progressive CLAD.We performed a retrospective study of all lung transplant ...
Vos, Robin, Vanden Eynde, Ruben, Ruttens, David, Verleden, Stijn E., Vanaudenaerde, Bart M., Dupont, Lieven J., Yserbyt, Jonas, Verbeken, Eric K., Neyrinck, Arne P., Van Raemdonck, Dirk E., Verleden, Geert M., Godinas, Laurent, Van Herck, Anke, Vanstapel, Arno, Sacreas, Annelore, Kaes, Janne, Heigl, Tobias, Ordies, Sofie, Schaevers, Veronique, De Leyn, Paul, Coosemans, Willy, Nafteux, Philippe, Decaluwe, Herbert, Van Veer, Hans, Depypere, Lieven, Frick, Anna E., Ceulemans, Laurens J., Weynand, Birgit, Emonds, Marie-Paule   +28 more
openaire   +3 more sources

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source